Collum L M, Akhtar J, McGettrick P
Trans Ophthalmol Soc U K (1962). 1985;104 ( Pt 6):629-32.
A double blind comparative study of oral acyclovir and acyclovir ophthalmic ointment was carried out on 29 patients with simple herpetic dendritic corneal ulceration. Patients were randomly allocated to the study. Healing was achieved in all fourteen patients treated with acyclovir ointment, and in fourteen out of fifteen patients treated with oral acyclovir. The mean healing time of 5.6 days was identical for both patient groups. There was no significant systemic or local side effects recorded in either group. The level of acyclovir in tear fluid was measured, and in patients receiving oral acyclovir the level was in excess of the ED50 of herpes simplex virus type 1.
对29例单纯疱疹性树枝状角膜溃疡患者进行了口服阿昔洛韦与阿昔洛韦眼膏的双盲对照研究。患者被随机分配到该研究中。使用阿昔洛韦眼膏治疗的14例患者全部治愈，口服阿昔洛韦治疗的15例患者中有14例治愈。两组患者的平均愈合时间均为5.6天。两组均未记录到显著的全身或局部副作用。对泪液中的阿昔洛韦水平进行了测量，接受口服阿昔洛韦的患者体内该水平超过了1型单纯疱疹病毒的半数有效剂量（ED50）。
