Iwashige H, Yamada K, Mure H, Maenohara S, Takao S, Ishizawa T, Shimazu H
First Dept. of Surgery, Kagoshima University School of Medicine.
Gan To Kagaku Ryoho. 1991 Apr;18(4):645-8.
A case of local recurrence of rectal cancer was successfully treated by UFT combined with two-route CDDP chemotherapy under the AT-II induced hypertension. UFT (600 mg/day) was orally administered every day. CDDP (75 mg/m2) was infused into the right internal iliac artery via subcutaneously grafted Infuse-a-port under hypertensive state induced by the AT-II (3 micrograms/min). Sodium thiosulfate was intravenously given to protect the CDDP induced nephrotoxicity. The recurrence tumor palpated by digital examination and revealed by MRI disappeared after the fourth two-route CDDP chemotherapy. The serum CEA level elevated before the treatment also normalized. This combined chemotherapy was considered to be an effective measure to cure the local recurrence of rectal cancer.
一例直肠癌局部复发患者在血管紧张素Ⅱ诱导的高血压状态下，采用优福定联合双途径顺铂化疗成功治愈。优福定每日口服给药（600毫克/天）。在血管紧张素Ⅱ（3微克/分钟）诱导的高血压状态下，通过皮下植入的输液港将顺铂（75毫克/平方米）注入右髂内动脉。静脉给予硫代硫酸钠以保护顺铂引起的肾毒性。在第四次双途径顺铂化疗后，通过直肠指检触及并经磁共振成像显示的复发肿瘤消失。治疗前升高的血清癌胚抗原水平也恢复正常。这种联合化疗被认为是治愈直肠癌局部复发的有效措施。
