Karatay Saliha, Yildirim Kadir, Uyanik Abdullah, Uzkeser Hulya, Kiziltunc Ahmet, Ugur Mahir, Baygutalp Fatih, Acemoglu Hamit
Department of Physical Medicine and Rehabilitation, Medical Faculty, Ataturk University, 25240 Erzurum, Turkey.
Ann Clin Lab Sci. 2010 Winter;40(1):10-4.
Serum homocysteine, folic acid, lipoprotein (a) (Lp(a)), fibrinogen, and C-reactive protein (CRP) concentrations and erythrocyte sedimentation rates (ESR) were measured in 52 patients with familial Mediterranean fever (FMF) during attack-free periods and in 30 healthy control subjects. Serum homocysteine levels were significantly higher in the FMF patients (median 17.8 microg/dl; range 5.6-80.8) than in controls (median 11.7; range 5.6-42.2; p = 0.013). Serum homocysteine levels were elevated above the upper reference limit (15 microg/dl) in 56% of the FMF patients compared to 27% of the controls (p = 0.011). Serum Lp(a) levels were significantly higher in the FMF patients (median 39.3 mg/dl; range 6.6-124.5) than in controls (median 27.2; range 11.1-78.1; p = 0.035). Serum Lp(a) levels were elevated above the upper reference limit (30 mg/dl) in 71% of the FMF patients compared to 47% of the controls (p = 0.028). The ESR, fibrinogen, CRP, and folic acid levels were similar in both groups. In conclusion, serum homocysteine and Lp(a) concentrations are often increased in FMF patients during attack-free periods. The elevated homocysteine and Lp(a) levels, which are markers of sub-clinical inflammation, may be mediators of atherosclerotic disease in FMF patients.
在52例家族性地中海热（FMF）患者的无发作期以及30名健康对照者中，检测了血清同型半胱氨酸、叶酸、脂蛋白(a)（Lp(a)）、纤维蛋白原、C反应蛋白（CRP）浓度以及红细胞沉降率（ESR）。FMF患者的血清同型半胱氨酸水平（中位数17.8微克/分升；范围5.6 - 80.8）显著高于对照组（中位数11.7；范围5.6 - 42.2；p = 0.013）。与27%的对照组相比，56%的FMF患者血清同型半胱氨酸水平高于参考上限（15微克/分升）（p = 0.011）。FMF患者的血清Lp(a)水平（中位数39.3毫克/分升；范围6.6 - 124.5）显著高于对照组（中位数27.2；范围11.1 - 78.1；p = 0.035）。与47%的对照组相比，71%的FMF患者血清Lp(a)水平高于参考上限（30毫克/分升）（p = 0.028）。两组的ESR、纤维蛋白原、CRP和叶酸水平相似。总之，在无发作期，FMF患者的血清同型半胱氨酸和Lp(a)浓度常常升高。升高的同型半胱氨酸和Lp(a)水平作为亚临床炎症的标志物，可能是FMF患者动脉粥样硬化疾病的介导因素。
