抗环瓜氨酸肽抗体与家族性地中海热无关。
Anti-cyclic citrullinated peptide antibodies are not associated with familial Mediterranean fever.
作者信息
Karatay Saliha, Yildirim Kadir, Erdal Akin, Uzkeser Hulya, Erdem Fazile Hatipoglu, Yanmaz Vefa
机构信息
Department of Physical Medicine and Rehabilitation, Medical Faculty, Ataturk University, 25240 Erzurum, Turkey.
出版信息
J Back Musculoskelet Rehabil. 2010;23(1):21-3. doi: 10.3233/BMR-2010-0243.
OBJECTIVE
This study investigated the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in familial Mediterranean fever (FMF) patients and controls.
MATERIAL AND METHODS
Forty-nine patients with FMF were enrolled (23 had a history of arthritis during attacks and 26 had no such history). Two control groups were enrolled: 20 patients with rheumatoid arthritis (RA) and 30 healthy individuals. Clinical and laboratory assessments of the FMF patients were performed during attack-free periods. Erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), rheumatoid factor (RF), and anti-CCP antibody levels were measured.
RESULTS
In RA patients' ESR and CRP levels, frequency of RF, and anti-CCP antibody levels were significantly higher than in both FMF patients and healthy controls (p 0.001). Moreover, anti-CCP was negative in all healthy controls as well as in all FMF patients.
CONCLUSION
Our results show that anti-CCP antibodies are not associated with FMF.
目的
本研究调查家族性地中海热（FMF）患者和对照组中抗环瓜氨酸肽（抗CCP）抗体的存在情况。
材料与方法
招募了49例FMF患者（23例在发作期间有关节炎病史，26例无此类病史）。招募了两个对照组：20例类风湿性关节炎（RA）患者和30名健康个体。在FMF患者无发作期间进行临床和实验室评估。测量红细胞沉降率（ESR）、血清C反应蛋白（CRP）、类风湿因子（RF）和抗CCP抗体水平。
结果
RA患者的ESR和CRP水平、RF频率以及抗CCP抗体水平均显著高于FMF患者和健康对照组（p<0.001）。此外，所有健康对照组以及所有FMF患者的抗CCP均为阴性。
结论
我们的结果表明抗CCP抗体与FMF无关。
Zotero 插件