中年社区志愿者的尿液氧化应激标志物与敌意呈正相关。
A urinary marker of oxidative stress covaries positively with hostility among midlife community volunteers.
机构信息
MS, Behavioral Immunology Laboratory, University of Pittsburgh, Old Engineering Hall, Suite 600, 3943 O'Hara St., Pittsburgh, PA 15260.
出版信息
Psychosom Med. 2010 Apr;72(3):273-80. doi: 10.1097/PSY.0b013e3181d0d72b. Epub 2010 Feb 2.
OBJECTIVE
Although not all findings are consistent, growing evidence suggests that individuals high in dispositional hostility are at elevated risk for cardiovascular disease and all-cause mortality; however, the mechanisms of these associations remain unclear. One possibility is that hostility is associated with oxidative stress. Here, we explore relationships between hostility and a measure of systemic oxidative stress among a mid-life sample.
METHODS
In a community sample of 223 adults aged 30 to 54 years (86% white, 50% female), oxidative stress was measured as the 24-hour urinary excretion of 8-hydroxy-2'-deoxyguanosine (8-OHdG). An abbreviated Cook Medley Hostility Scale was used to measure dimensions of hostility.
RESULTS
Regression analyses controlling for demographic characteristics and cardiovascular risk factors showed a positive relationship of 8-OHdG with total hostility (beta = 0.003, p = .03) and hostile affect (beta = 0.018, p < .001).
CONCLUSIONS
These findings provide evidence that dispositional hostility, and in particular, hostile affect, covary positively with systemic oxidative stress, raising the possibility that oxidative stress contributes to the pathogenicity of hostile attributes.
目的
尽管并非所有研究结果都一致，但越来越多的证据表明，性格上具有敌意的个体患心血管疾病和全因死亡率的风险增加；然而，这些关联的机制仍不清楚。一种可能性是敌意与氧化应激有关。在这里，我们在中年人群中探索了敌意与全身氧化应激指标之间的关系。
方法
在一项年龄在 30 至 54 岁的 223 名成年人（86%为白人，50%为女性）的社区样本中，通过 24 小时尿液中 8-羟基-2'-脱氧鸟苷（8-OHdG）的排泄来衡量氧化应激。采用简化的库克-梅德利敌意量表来衡量敌意的不同维度。
结果
在控制了人口统计学特征和心血管危险因素后，回归分析显示 8-OHdG 与总体敌意（β=0.003，p=0.03）和敌意情绪（β=0.018，p<0.001）呈正相关。
结论
这些发现提供了证据表明，性格上的敌意，特别是敌意情绪，与全身氧化应激呈正相关，这增加了氧化应激可能导致敌意特征发病的可能性。
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