Ray W A, Griffin M R, Malcolm E
Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tenn 37232-2637.
Arch Intern Med. 1991 Apr;151(4):754-6.
To determine whether cyclic antidepressants increase the risk of hip fracture, we conducted a population-based case-control study in the Canadian province of Saskatchewan. We identified 4501 persons 65 years of age or older with a first hospitalization for hip fracture between 1977 and 1985 and 24,041 comparable controls. Current antidepressant users had a relative risk of hip fracture of 1.6 (95% confidence interval, 1.3 to 1.9). Medical record review for a sample of 164 cases suggested this finding was not due to confounding by body mass, impaired ambulation, functional status, or dementia.
为了确定三环类抗抑郁药是否会增加髋部骨折的风险，我们在加拿大萨斯喀彻温省开展了一项基于人群的病例对照研究。我们确定了4501名65岁及以上的老人，他们在1977年至1985年间因髋部骨折首次住院，以及24041名可作比较的对照者。当前服用抗抑郁药的人发生髋部骨折的相对风险为1.6（95%置信区间为1.3至1.9）。对164例病例样本的病历审查表明，这一发现并非由体重、行走障碍、功能状态或痴呆症的混杂因素所致。
