Epidemiol Prev. 2009 Jul-Oct;33(4-5 Suppl 1):1-168.
the aim of this collaborative project of the Italian Network of Cancer Registries (Airtum; www.registri-tumori.it) was to analyse cancer incidence and mortality trends in Italy with special reference to the period 1998-2005.
the study was based on the Airtum database, which collects and checks data from all the Airtum registries. The present study was based on 20 general and 2 specific populationbased cancer registries. Overall, we analysed 818,017 incident cases and 342,444 cancer deaths for the time period 1998-2005. Seventy percent of the analysed population was from the North of Italy, 17% from the Centre, and 13% from the South. A joinpoint analysis was carried out to detect the point in time where the trend changed; trends are described by means of the estimated annual percent change (APC), with appropriate 95% confidence intervals. Crude and standardized incidence and mortality rates were computed for 36 cancer sites, for both sexes, three age-classes (0-49, 50-69 and 70+ years), and three geographic areas (North, Centre, and South of Italy). Specific chapters are devoted to long-term trends (1986-2005), differences among age-groups, and international comparisons.
In 1998-2005, cancer mortality for all sites showed a statistically significant decrease among men (APC - 1.7) and women (- 0.8). Mortality significantly decreased in both sexes for stomach cancer, rectum cancer, liver cancer, and Hodgkin lymphoma. Mortality also decreased among men for cancers of the upper aerodigestive tract, oesophagus, lung, prostate, urinary bladder, and leukaemia. Among women mortality decreased for cancers of the colon, bone, breast, and uterus not otherwise specified. An increase in mortality was recorded for lung cancer among women (+1.5) and melanoma among men (+2.6). Incidence for all cancers together (except non-melanoma skin cancers) increased among men (APC +0.3) and remained stable among women. Cancer sites which showed increasing incidence were thyroid and melanoma in both sexes, colon, testis, soft tissue among men, and lung and Hodgkin lymphoma among women. For several cancer sites incidence decreased, e.g., stomach and Kaposi sarcoma (men and women), upper aerodigestive tract, oesophagus, lung, urinary bladder, myeloma and leukaemia (men), gallbladder, cervix uteri and ovary (women).
this monograph presents a detailed description of cancer incidence and mortality trends in Italy. It is based on the Italian Network of Cancer Registries which presently covers about one-third of the whole Italian population. This monograph is a useful scientific tool for all those, be they researchers or public health administrators, who are involved in the fields of cancer prevention and care.
意大利癌症登记网络（Airtum；www.registri-tumori.it）这一合作项目的目的是分析意大利癌症发病率和死亡率趋势，特别关注1998 - 2005年期间。
该研究基于Airtum数据库，该数据库收集并核查来自所有Airtum登记处的数据。本研究基于20个普通和2个特定的基于人群的癌症登记处。总体而言，我们分析了1998 - 2005年期间818,017例新发病例和342,444例癌症死亡病例。分析人群的70%来自意大利北部，17%来自中部，13%来自南部。进行了连接点分析以检测趋势发生变化的时间点；趋势通过估计的年变化百分比（APC）及适当的95%置信区间来描述。计算了36个癌症部位、男女两性、三个年龄组（0 - 49岁、50 - 69岁和70岁及以上）以及三个地理区域（意大利北部、中部和南部）的粗发病率和标准化发病率及死亡率。特定章节专门论述长期趋势（1986 - 2005年）、年龄组间差异以及国际比较。
在1998 - 2005年期间，所有部位的癌症死亡率在男性（APC - 1.7）和女性（- 0.8）中均呈现出统计学显著下降。胃癌、直肠癌、肝癌和霍奇金淋巴瘤的死亡率在男女两性中均显著下降。男性中，上消化道、食管、肺、前列腺、膀胱和白血病的癌症死亡率也有所下降。女性中，结肠、骨、乳腺和未另行指定的子宫癌症的死亡率下降。女性肺癌（+1.5）和男性黑色素瘤（+2.6）的死亡率有所上升。男性中所有癌症（非黑色素瘤皮肤癌除外）的发病率上升（APC +0.3），女性中则保持稳定。发病率上升的癌症部位包括男女两性的甲状腺和黑色素瘤、男性的结肠、睾丸、软组织，以及女性的肺和霍奇金淋巴瘤。若干癌症部位的发病率下降，例如胃癌和卡波西肉瘤（男性和女性）、上消化道、食管、肺、膀胱、骨髓瘤和白血病（男性）、胆囊、子宫颈和卵巢（女性）。
本专著详细描述了意大利癌症发病率和死亡率趋势。它基于意大利癌症登记网络，该网络目前覆盖约三分之一的意大利总人口。本专著对于所有参与癌症预防和护理领域的人员（无论是研究人员还是公共卫生管理人员）而言，都是一个有用的科学工具。
