Institute of Liver Studies, King's College Hospital, London, United Kingdom. john.o'
Transplantation. 2010 Mar 15;89(5):627-32. doi: 10.1097/TP.0b013e3181ca87b0.
Nonadherence to medical treatment in transplant recipients is a major risk factor for graft rejection episodes, and it has significant financial implications. Despite its importance, there is a lack of common understanding across the disciplines involved of the key issues driving nonadherence.
A qualitative study, comprising a multidisciplinary workshop, followed by a consultation exercise to validate its outcomes, was initiated to gain further insight into nonadherence behavior and to identify priorities for optimizing adherence to posttransplantation regimens.
Eight statements relating to actions necessary to maximize adherence to posttransplantation medication were developed and offered for validation. All but one of these attracted a median score of 9 on an agreement scale of 1 to 10, where 10 was the highest level of agreement.
The outcomes generate a structure that will facilitate communication and understanding and informing clinical practice and future research.
器官移植受者不遵医嘱是导致移植物排斥反应的主要危险因素，而且还会带来重大的经济影响。尽管其重要性不言而喻，但各相关学科之间对于导致不遵医嘱的关键问题缺乏共识。
开展了一项定性研究，包括一次多学科研讨会，以及一项对研究结果进行验证的咨询活动，以深入了解不遵医嘱行为，并确定优化移植后治疗方案依从性的重点。
制定了 8 项与最大限度提高移植后药物治疗依从性相关的行动方案，并提供了验证。这 8 项方案中除 1 项外，其余均获得了 1 到 10 分的协议评分，其中 10 分为最高分。
研究结果提供了一个框架，有助于促进沟通和理解，为临床实践和未来研究提供信息。
