Truong L D, Yoshikawa Y, Mawad J, Lederer E
Department of Pathology, Methodist Hospital and Baylor College of Medicine, Houston 77030.
Arch Pathol Lab Med. 1991 Apr;115(4):382-5.
Glomerular lesions are frequently seen in renal allografts and are usually classified into transplant glomerulopathy and posttransplant glomerulonephritis. The latter is subdivided into donor-related, de novo, and recurrent glomerulonephritis. We report a distinctive posttransplant glomerular lesion that does not fit into any diagnostic category mentioned above. This lesion was characterized by the presence of global, diffuse, subepithelial, electron-lucent deposits, in addition to the usual features of transplant glomerulopathy. This unusual usual lesion, to the best of our knowledge, has been reported only once and, indeed, was recognized in only one of 297 renal allograft biopsy specimens in our file. Although the classification, pathogenesis, and origin of this rare lesion remain to be elucidated, it can be associated with nephrotic syndrome, deterioration of renal function, and eventual graft loss.
肾小球病变在肾移植中很常见，通常分为移植性肾小球病和移植后肾小球肾炎。后者又细分为供体相关、新发和复发性肾小球肾炎。我们报告了一种独特的移植后肾小球病变，不属于上述任何诊断类别。除了移植性肾小球病的常见特征外，这种病变的特点是存在全球性、弥漫性、上皮下、电子透明沉积物。据我们所知，这种不寻常的病变仅被报道过一次，实际上，在我们档案中的297份肾移植活检标本中，只有1份被识别出来。尽管这种罕见病变的分类、发病机制和起源仍有待阐明，但它可能与肾病综合征、肾功能恶化以及最终的移植肾丢失有关。
