Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
Curr Opin Organ Transplant. 2010 Apr;15(2):156-9. doi: 10.1097/MOT.0b013e328337343f.
The problem of organ shortage continuously emphasizes the importance of proper donor management and selection, organ preservation and recipient selection and treatment. This review summarizes state of the art of cardiac allograft preservation with special regard to recent clinical and experimental findings.
Over the past years no major strategy changes have found their way to the clinical setting of cardiac allograft preservation. Static, antegrade, cold, crystalloid flush perfusion is still the commonly used technique to preserve the heart. The importance of electrolyte composition, substrates and ischemia/reperfusion injury inhibiting additives are discussed with special attention to recent findings. Machine perfusion during preservation has regained attention over recent years and has led to the first clinical safety and feasibility trials in Europe and the USA.
No major changes were introduced in the technique of heart preservation over the past years. Many new ideas based upon experimental data were postulated but still have to find their way to the clinical setting.There is a renewed interest in mechanical perfusion. Everyone is curiously awaiting the first clinical reports.
供体器官短缺问题不断强调了妥善的供体管理和选择、器官保存和受者选择与治疗的重要性。本综述总结了心脏移植保存的最新技术，特别关注了最近的临床和实验发现。
在过去的几年里，没有重大的策略改变被应用于心脏移植保存的临床实践中。静态、顺行、低温、晶体冲洗灌注仍然是保存心脏的常用技术。本文讨论了电解质组成、底物和缺血/再灌注损伤抑制添加剂的重要性，并特别关注了最近的发现。近年来，保存过程中的机器灌注重新引起了人们的关注，并导致了欧洲和美国的首次临床安全性和可行性试验。
在过去的几年中，心脏保存技术没有发生重大变化。许多基于实验数据的新想法被提出来，但仍有待于在临床实践中应用。机械灌注再次引起了人们的兴趣。每个人都好奇地等待着第一批临床报告。
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