Malone James, Robbins K Thomas
SimmonsCooper Cancer Institute at SIU, Southern Illinois University School of Medicine, USA.
Curr Opin Otolaryngol Head Neck Surg. 2010 Apr;18(2):89-94. doi: 10.1097/MOO.0b013e32833693e7.
Chemoradiation has become a common approach in the treatment of advanced head and neck cancer. Its effectiveness in eradicating associated nodal metastases has resulted in modifications in the traditional paradigms for managing this aspect.
Regardless of the pretreatment neck staging, patients who have a complete response to chemoradiation are unlikely to have residual viable tumor in this region, thus putting in question the need for planned neck dissection. F-Fluorodeoxyglucose positron emission tomography/computed tomography has become a standard tool to assess disease response to chemoradiotherapy, including the associated nodal disease. However, there remains an ongoing debate about its timing. The extent of neck dissection is trending toward an approach for selective procedures in order to minimize the long-term sequelae of extensive neck fibrosis.
Post-chemoradiotherapy neck dissection is an effective procedure for selected patients with advanced head and neck cancer but is becoming a less needed intervention.
放化疗已成为晚期头颈癌治疗的常用方法。其在根除相关区域淋巴结转移方面的有效性导致了传统治疗模式在这方面的改变。
无论治疗前颈部分期如何,对放化疗有完全反应的患者该区域不太可能有残留的存活肿瘤,因此对计划性颈清扫术的必要性提出了质疑。F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描已成为评估放化疗疾病反应(包括相关区域淋巴结疾病)的标准工具。然而,关于其检查时机仍存在争议。颈清扫术的范围正趋向于采用选择性手术方式,以尽量减少广泛颈部纤维化的长期后遗症。
放化疗后颈清扫术对部分晚期头颈癌患者是一种有效的手术,但正逐渐成为一种不太必要的干预措施。