Huber Gerhard Frank
HNO-Klinik, Kantonsspital St. Gallen, Rorschacher Strasse 95, 9007 St. Gallen, Switzerland.
Zentrum für Ohren-, Nasen-, Hals- und Plastische Gesichtschirurgie, Klinik Hirslanden, Witellikerstrasse 40, 8032 Zürich, Switzerland.
Cancers (Basel). 2021 May 18;13(10):2457. doi: 10.3390/cancers13102457.
Except for HPV-induced cancers of the oropharynx, survival rates in patients with squamous cell carcinoma of the head and neck (HNSCC) have not changed substantially over the last decades. Salvage surgery plays an important role where primary treatment was unsuccessful since 50% of advanced-stage patients relapse after nonsurgical primary treatment. Depending on a variety of factors, a considerable number of patients in whom primary treatment was not successful can still be cured by salvage surgery. It is the goal of this review to elucidate these factors with the aim to counsel patients and their relatives realistically about the chances of being cured.
除了人乳头瘤病毒（HPV）引发的口咽癌外，在过去几十年中，头颈部鳞状细胞癌（HNSCC）患者的生存率并无显著变化。挽救性手术在初始治疗未成功的情况下发挥着重要作用，因为50%的晚期患者在非手术初始治疗后会复发。根据多种因素，相当一部分初始治疗未成功的患者仍可通过挽救性手术治愈。本综述的目的是阐明这些因素，以便切实地为患者及其亲属提供关于治愈可能性的咨询。
