The Research and Development Unit, Jämtland County Council, Ostersund, Sweden.
Int J Obes (Lond). 2010 May;34(5):878-85. doi: 10.1038/ijo.2010.19. Epub 2010 Feb 2.
Leptin predicts cardiovascular diseases and type 2 diabetes, diseases to which Asian Indians are highly susceptible. As a risk marker, leptin's intra-individual and seasonal stability is unstudied and only small studies have compared leptin levels in Asian Indians with other populations. The aim of this study was to explore ethnicity related differences in leptin levels and its intra-individual and seasonal stability.
Leptin and anthropometric data from the northern Sweden MONICA (3513 Europids) and the Mauritius Non-communicable Disease (2480 Asian Indians and Creoles) studies were used. In both studies men and women, 25- to 74-year old, participated in both an initial population survey and a follow-up after 5-13 years. For the analysis of seasonal leptin variation, a subset of 1780 participants, 30- to 60-year old, in the Västerbotten Intervention Project was used.
Asian Indian men and women had higher levels of leptin, leptin per body mass index (BMI) unit (leptin/BMI) or per cm in waist circumference (WC; leptin/waist) than Creoles and Europids when adjusted for BMI (all P<0.0005) or WC (all P<0.005). In men, Creoles had higher leptin, leptin/BMI and leptin/waist than Europids when adjusted for BMI or WC (all P<0.0005). In women, Creoles had higher leptin/BMI and leptin/waist than Europids only when adjusted for WC (P<0.0005). Asian Indian ethnicity in both sexes, and Creole ethnicity in men, was independently associated with high leptin levels. The intra-class correlation for leptin was similar (0.6-0.7), independently of sex, ethnicity or follow-up time. No seasonal variation in leptin levels was seen.
Asian Indians have higher levels of leptin, leptin/BMI and leptin/waist than Creoles and Europids. Leptin has a high intra-individual stability and seasonal leptin variation does not appear to explain the ethnic differences observed here.
瘦素可预测心血管疾病和 2 型糖尿病，而亚洲裔印度人极易患上这些疾病。作为一种风险标志物，瘦素的个体内和季节性稳定性尚未得到研究，只有少数研究比较了亚洲裔印度人的瘦素水平与其他人群。本研究旨在探讨瘦素水平及其个体内和季节性稳定性的种族相关差异。
使用来自瑞典北部 MONICA（3513 名欧洲人）和毛里求斯非传染性疾病（2480 名亚洲裔印度人和克里奥尔人）研究的瘦素和人体测量数据。在这两项研究中，年龄在 25-74 岁的男性和女性均参加了初始人群调查和 5-13 年后的随访。为了分析季节性瘦素变化，使用了维斯特博滕干预项目中年龄在 30-60 岁的 1780 名参与者的一个子集。
调整 BMI（均 P<0.0005）或腰围（均 P<0.005）后，与克里奥尔人和欧洲人相比，亚洲裔印度男性和女性的瘦素、瘦素/体重指数（BMI）单位（瘦素/BMI）或瘦素/腰围（WC；瘦素/腰围）水平更高。调整 BMI 或 WC 后，男性克里奥尔人的瘦素、瘦素/BMI 和瘦素/腰围均高于欧洲人（均 P<0.0005）。调整 WC 后，女性克里奥尔人的瘦素/BMI 和瘦素/腰围高于欧洲人（均 P<0.0005）。在两性中，亚洲裔印度人的种族以及男性中的克里奥尔人种族均与高瘦素水平独立相关。瘦素的组内相关相似（0.6-0.7），与性别、种族或随访时间无关。未观察到瘦素水平的季节性变化。
亚洲裔印度人的瘦素、瘦素/BMI 和瘦素/腰围水平高于克里奥尔人和欧洲人。瘦素具有较高的个体内稳定性，且季节性瘦素变化似乎无法解释本研究中观察到的种族差异。
