乙醇对大鼠唾液腺前列腺素生成的损害作用。

Impairment by ethanol of prostaglandin production in rat salivary glands.

作者信息

Wu-Wang C Y, Wang S L, Lim C, Slomiany A, Slomiany B L

机构信息

Research Center, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark 07103.

出版信息

Arch Oral Biol. 1991;36(1):9-13. doi: 10.1016/0003-9969(91)90048-y.

DOI:10.1016/0003-9969(91)90048-y

PMID:2012531

Abstract

Sublingual salivary acini and submandibular tissue were incubated in DMEM medium in the presence of various concentrations (0-5%) of ethanol and the content of the three major prostaglandins, PGE2, PGF2 alpha and 6-keto-PGF1 alpha, were determined by radioimmunoassay. In In the sublingual gland, ethanol caused a decrease in PGE2 and PGF2 alpha levels, but had no effect on 6-keto-PGF1 alpha, while all three prostaglandins were affected in the submandibular gland. At 2.5% ethanol, the production of PGF2 alpha and PGE2 in sublingual gland decreased by 10% and reached maximum inhibition at 5% ethanol, at which concentration there was a 20 and 30% decrease in their levels. In submandibular gland, 2.5% ethanol caused a 20% decrease in PGE2, 30% in PGF2 alpha and 50% in 6-keto-PGF1 alpha; 40% inhibition in PGE2, 57% in 6-keto-PGF1 alpha and 65% in PGF2 alpha occurred in the presence of 5% ethanol. These findings suggest that alcohol impairs the function of salivary glands by inhibiting prostaglandin production.

摘要

将舌下唾液腺泡和下颌下组织置于含有不同浓度（0 - 5%）乙醇的DMEM培养基中孵育，通过放射免疫分析法测定三种主要前列腺素PGE2、PGF2α和6 - 酮 - PGF1α的含量。在舌下腺中，乙醇导致PGE2和PGF2α水平降低，但对6 - 酮 - PGF1α没有影响，而在下颌下腺中，所有三种前列腺素均受到影响。在2.5%乙醇浓度下，舌下腺中PGF2α和PGE2的产生量减少了10%，在5%乙醇浓度时达到最大抑制，此时它们的水平分别下降了20%和30%。在下颌下腺中，2.5%乙醇导致PGE2下降20%，PGF2α下降30%，6 - 酮 - PGF1α下降50%；在5%乙醇存在时，PGE2抑制40%，6 - 酮 - PGF1α抑制57%，PGF2α抑制65%。这些发现表明，酒精通过抑制前列腺素的产生损害唾液腺的功能。