Guthoff R F, Berger R W, Winkler P, Helmke K, Chumbley L C
Department of Ophthalmology, Hamburg University Hospital-Eppendorf, Federal Republic of Germany.
Arch Ophthalmol. 1991 Apr;109(4):537-41. doi: 10.1001/archopht.1991.01080040105038.
Doppler shifts were detected using duplex and color Doppler scanning in 41 of 42 patients with malignant melanomas of the uvea. Mean maximum tumor systolic velocity was 18.8 +/- 7.6 cm/s. Time-averaged maximum velocity in the tumor vessels was 12.3 +/- 5.3 cm/s. Maximum tumor velocity increased in four of eight tumors and was unchanged or had diminished in the other four 2 to 3 days after ruthenium plaque irradiation. Doppler shifts were undetectable in three tumors, markedly reduced in three tumors, and unchanged in one tumor 1 to 4 months after treatment. We detected minimal non-pulse-synchronized Doppler shifts in one of three tumors, and no shifts in the remaining two tumors 1 1/2 to 4 years after therapy. Color duplex scanning allowed a rapid overview of tumor vasculature and facilitated study of individual vessels.
在42例葡萄膜恶性黑色素瘤患者中，41例通过双功和彩色多普勒扫描检测到了多普勒频移。肿瘤平均最大收缩期速度为18.8±7.6厘米/秒。肿瘤血管的时间平均最大速度为12.3±5.3厘米/秒。在钌斑照射后2至3天，8个肿瘤中有4个肿瘤的最大速度增加，另外4个肿瘤的最大速度未变或降低。治疗后1至4个月，3个肿瘤未检测到多普勒频移，3个肿瘤明显降低，1个肿瘤未变。治疗后1年半至4年，在3个肿瘤中的1个检测到最小的非脉冲同步多普勒频移，其余2个肿瘤未检测到频移。彩色双功扫描能够快速全面地观察肿瘤血管系统，并便于对单个血管进行研究。
