人类肿瘤有丝分裂指数和标记指数固有波动的评估。

Assessment of inherent fluctuations of mitotic and labelling indices of human tumours.

作者信息

Aherne W A, Camplejohn R S, Al-Wiswasy M, Ford D, Kellerer A M

出版信息

Br J Cancer. 1977 Nov;36(5):577-82. doi: 10.1038/bjc.1977.234.

DOI:10.1038/bjc.1977.234

PMID:201259

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2025402/

Abstract

A method is presented to evaluate the influence of statistical errors and inherent variation on the determination of mitotic and labelling indices of human tumours. In most of the experiments reported here, sufficient cells were counted to yield a statistical error which is small in comparison to the inherent differences in the proliferative indices, both between different sites in the same tumour and between different tumours of the same histological type. These inherent fluctuations are, theefore, a critical factor in cell kinetic studies of human tumours.

摘要

本文提出了一种方法，用于评估统计误差和固有变异对人类肿瘤有丝分裂指数和标记指数测定的影响。在本文报道的大多数实验中，所计数的细胞数量足以产生一个与增殖指数的固有差异相比很小的统计误差，这种固有差异既存在于同一肿瘤的不同部位之间，也存在于同一组织学类型的不同肿瘤之间。因此，这些固有波动是人类肿瘤细胞动力学研究中的一个关键因素。