软骨组织的传输特性。
TRANSPORT PROPERTIES OF CARTILAGINOUS TISSUES.
作者信息
Jackson Ar, Gu Wy
机构信息
Tissue Biomechanics Lab, Dept of Biomedical Engineering, University of Miami, Coral Gables, FL.
出版信息
Curr Rheumatol Rev. 2009 Feb 1;5(1):40. doi: 10.2174/157339709787315320.
Abstract
Cartilaginous tissues, such as articular cartilage and intervertebral disc, are avascular tissues which rely on transport for cellular nutrition. Comprehensive knowledge of transport properties in such tissues is therefore necessary in the understanding of nutritional supply to cells. Furthermore, poor cellular nutrition in cartilaginous tissues is believed to be a primary source of tissue degeneration, which may result in osteoarthritis (OA) or disc degeneration. In this mini-review, we present an overview of the current status of the study of transport properties and behavior in cartilaginous tissues. The mechanisms of transport in these tissues, as well as experimental approaches to measuring transport properties and results obtained are discussed. The current status of bioreactors used in cartilage tissue engineering is also presented.
摘要
软骨组织，如关节软骨和椎间盘，是无血管组织，依靠转运来获取细胞营养。因此，全面了解此类组织中的转运特性对于理解细胞的营养供应至关重要。此外，软骨组织中细胞营养不足被认为是组织退化的主要原因，这可能导致骨关节炎（OA）或椎间盘退变。在本综述中，我们概述了软骨组织转运特性及行为的研究现状。讨论了这些组织中的转运机制，以及测量转运特性的实验方法和所得结果。还介绍了软骨组织工程中使用的生物反应器的现状。
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