Williams David R, Walsh Martin J, Claeboe Christopher D, Zorn Nicolas
Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405-7102, USA.
Pure Appl Chem. 2009;81(2):181. doi: 10.1351/PAC-CON-08-07-23.
The process of allylic transposition in S(E)' reactions is a significant construct for synthesis. The flexibility of a variety of allylation strategies provides for the rational design of pathways to a diverse array of complex targets. Our recent studies of S(E)' reactions will examine issues of stereoselectivity and efficiency in the context of applications toward the synthesis of marine natural products such as the xenicane diterpenes, which feature the strained E-cyclononene ring system, and peloruside A, a 16-membered macrocyclic lactone.
在S(E)'反应中烯丙基转位过程是合成的一个重要构建方式。多种烯丙基化策略的灵活性为合理设计通向各种复杂目标物的途径提供了可能。我们最近对S(E)'反应的研究将在应用于合成海洋天然产物（如具有张力E-环壬烯环系的异海松烷二萜类化合物以及16元大环内酯类化合物peloruside A）的背景下，考察立体选择性和效率问题。
