Department of Pharmaceutical Chemistry, Pharmacy Faculty, Salamanca University, Campus Miguel de Unamuno, Salamanca, Spain.
Mar Drugs. 2010 Nov 24;8(12):2849-70. doi: 10.3390/md8122849.
The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities. The cytotoxic and antiproliferative properties of many natural sesquiterpene quinones and hydroquinones from sponges of the order Dictyoceratida, such as avarol, avarone, illimaquinone, nakijiquinone and bolinaquinone, offer promising opportunities for the development of new antitumor agents. The present review summarizes the structure and cytotoxicity of natural terpenequinones/hydroquinones and their bioactive analogues and derivatives.
1,4-苯醌部分是许多化合物的常见结构特征，由于其广泛的生物活性而受到极大关注。来自盘形纲海绵的许多天然倍半萜醌和对苯二酚的细胞毒性和抗增殖特性，如avarol、avarone、illimaquinone、nakijiquinone 和 bolinaquinone，为开发新的抗肿瘤药物提供了有希望的机会。本综述总结了天然萜醌/对苯二酚及其生物活性类似物和衍生物的结构和细胞毒性。
