CD8+ T cell control of HIV--a known unknown.
作者信息
Davenport Miles P, Petravic Janka
机构信息
Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia.
出版信息
PLoS Pathog. 2010 Jan 29;6(1):e1000728. doi: 10.1371/journal.ppat.1000728.
Abstract
摘要
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本文引用的文献
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In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells.体内 CD8+ T 细胞对 SIV 病毒血症的抑制作用不是由 CTL 清除感染细胞引起的。
PLoS Pathog. 2010 Jan 29;6(1):e1000748. doi: 10.1371/journal.ppat.1000748.
2
CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells.CD8+ 淋巴细胞可控制 SIVmac239 感染的恒河猴中的病毒复制，而不会减少感染细胞的寿命。
PLoS Pathog. 2010 Jan 29;6(1):e1000747. doi: 10.1371/journal.ppat.1000747.
3
Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.CD8 +淋巴细胞耗竭可诱导CD4 + /CCR5 + T细胞显著扩增，但这并不能解释SIV发病机制的加速。
J Exp Med. 2009 Jul 6;206(7):1575-88. doi: 10.1084/jem.20090356. Epub 2009 Jun 22.
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Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.CD8 + T细胞的溶细胞颗粒装载是与免疫控制相关的HIV感染细胞清除所必需的。
Immunity. 2008 Dec 19;29(6):1009-21. doi: 10.1016/j.immuni.2008.10.010. Epub 2008 Dec 8.
5
Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover.CD8 + T细胞对HIV-1复制的卓越控制体现在它们的亲和力、多功能性和克隆更新上。
J Exp Med. 2007 Oct 1;204(10):2473-85. doi: 10.1084/jem.20070784. Epub 2007 Sep 24.
6
Understanding the mechanisms and limitations of immune control of HIV.了解HIV免疫控制的机制和局限性。
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Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression.针对gag的CD8 + T淋巴细胞在艾滋病病毒整合和病毒蛋白表达之前就能识别被感染的细胞。
J Immunol. 2007 Mar 1;178(5):2746-54. doi: 10.4049/jimmunol.178.5.2746.
8
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells.HIV非进展者优先维持高度功能性的HIV特异性CD8 + T细胞。
Blood. 2006 Jun 15;107(12):4781-9. doi: 10.1182/blood-2005-12-4818. Epub 2006 Feb 7.
9
High-potency human immunodeficiency virus vaccination leads to delayed and reduced CD8+ T-cell expansion but improved virus control.高效力的人类免疫缺陷病毒疫苗接种导致CD8 + T细胞扩增延迟且减少，但病毒控制得到改善。
J Virol. 2005 Aug;79(15):10059-62. doi: 10.1128/JVI.79.15.10059-10062.2005.
10
Enhanced cellular immunity in macaques following a novel peptide immunotherapy.新型肽免疫疗法后猕猴细胞免疫增强
J Virol. 2005 Mar;79(6):3748-57. doi: 10.1128/JVI.79.6.3748-3757.2005.
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