使用三芳基硼氧烷作为芳基源，通过连续流动对映选择性芳基化反应合成醛类化合物。
Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups.
机构信息
Institute of Chemical Research of Catalonia, Avinguda Països Catalans, Tarragona, Spain.
出版信息
Beilstein J Org Chem. 2009 Oct 15;5:56. doi: 10.3762/bjoc.5.56.
Abstract
A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.
摘要
介绍了一种从醛合成对映体富集的二芳基甲醇的连续流系统。该系统使用氨基醇功能化聚苯乙烯树脂作为催化剂，芳基化试剂通过三芳基硼氧烷与二乙基锌的转金属化方便地制备。
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