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显微外科绝育术逆转——现今这在临床上仍有意义吗?

Microsurgical reversal of sterilisation - is this still clinically relevant today?

机构信息

Reproductive Medicine Department, KK Women's and Children's Hospital, Singapore.

出版信息

Ann Acad Med Singap. 2010 Jan;39(1):22-6.

Abstract

INTRODUCTION

Women with previous tubal sterilisation seeking fertility are faced with treatment options of reconstructive tubal surgery or in vitro fertilisation (IVF) techniques. The aim was to assess the current viability of tubal anastomosis in a local clinical practice.

MATERIALS AND METHODS

A retrospective cohort review of all sterilisation reversal cases from January 1998 to January 2008. The main outcome measures included fi rst pregnancy success and live birth after surgery. Subsequent live births, ectopic pregnancies, miscarriages, duration of surgery and hospitalisation within the study period were also reported. We included cases aged less than 40 years, without any known semen abnormalities, and performed by only one operator. Cases with only unilateral reversal were excluded.

RESULTS

Nineteen cases with previous Filshie clip ligation (9 laparoscopic/10 open) were reviewed. Cumulative pregnancy rates with surgery were 47.4% (<6 months), 57.9% (6 to 12 months), 68.4% (12 to 48 months) and 73.7% (>48 months). Pregnancy (77.8% vs 70.0%) and live birth rates (66.7% vs 60.0%) were similar between laparoscopy and open surgery. The mean interval to pregnancy was marginally lower via laparoscopy (11.3 vs 13.6 months). Hospitalisation stay was significantly halved (1.43 vs 3.00 days) but ectopic pregnancies were increased 3-fold (3 vs 1) with laparoscopy. Compared with IVF, the estimated average cost per delivery for laparoscopic reversal was reduced for laparoscopic reversal with no multiple pregnancies.

CONCLUSION

Our results favour surgical reversal after sterilisation for patients younger than 40 years old. It avoids hyperstimulation risks and the economic burdens associated with multiple pregnancies. Where expertise is available, laparoscopic reversal should be performed.

摘要

介绍

寻求生育的既往输卵管绝育妇女面临着重建输卵管手术或体外受精(IVF)技术的治疗选择。目的是评估当地临床实践中输卵管吻合术的当前可行性。

材料和方法

回顾性队列研究了 1998 年 1 月至 2008 年 1 月所有绝育复通病例。主要结局指标包括手术后首次妊娠成功和活产。报告了随后的活产、异位妊娠、流产、手术持续时间和研究期间的住院时间。我们纳入了年龄小于 40 岁、无明显精液异常且仅由一名手术医生进行的病例。排除了仅单侧复通的病例。

结果

共回顾了 19 例既往 Filshie 夹结扎(9 例腹腔镜/10 例开放)的病例。手术后累积妊娠率分别为 47.4%(<6 个月)、57.9%(6-12 个月)、68.4%(12-48 个月)和 73.7%(>48 个月)。腹腔镜组和开放组的妊娠率(77.8% vs 70.0%)和活产率(66.7% vs 60.0%)相似。腹腔镜组妊娠时间平均略短(11.3 个月 vs 13.6 个月)。住院时间明显减半(1.43 天 vs 3.00 天),但腹腔镜组异位妊娠增加 3 倍(3 例 vs 1 例)。与 IVF 相比,腹腔镜复通术无多胎妊娠时,每分娩的估计平均成本降低。

结论

对于年龄小于 40 岁的患者,我们的结果倾向于绝育后手术复通。它避免了超刺激风险和与多胎妊娠相关的经济负担。在具备专业知识的情况下,应进行腹腔镜复通术。

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