Sá Emmanuela Quental Callou de, Sá Francisco Carleial Feijó de, Guedes Alexis Dourado, Verreschi Ieda Therezinha do Nascimento
Escola Paulista de Medicina, Unifesp, São Paulo, SP, Brasil.
Arq Bras Endocrinol Metabol. 2009 Nov;53(8):915-22. doi: 10.1590/s0004-27302009000800004.
Cardiovascular diseases (CVD) represent the main cause of death in Brazil. Men die more of coronary artery disease and they have higher levels of testosterone than women. However, recent studies indicate that androgens can have beneficial and/or neutral effect in the male cardiovascular system. Low levels of endogenous testosterone have been involved with the presence of some components of the metabolic syndrome including dyslipidemia, visceral obesity, hypertension and thrombus formation process. Consistent data on the relationship between testosterone and vascular reactivity, atherosclerosis and cardiovascular mortality in men are rare, with the results of available studies presenting contradictions. Large randomized and prospective trials are needed to evaluate androgen-specific function in male CVD so that better conclusions can be established.
心血管疾病（CVD）是巴西主要的死亡原因。男性死于冠状动脉疾病的人数更多，且他们的睾酮水平高于女性。然而，最近的研究表明，雄激素对男性心血管系统可能具有有益和/或中性作用。内源性睾酮水平低与代谢综合征的某些成分有关，包括血脂异常、内脏肥胖、高血压和血栓形成过程。关于睾酮与男性血管反应性、动脉粥样硬化和心血管死亡率之间关系的一致数据很少，现有研究结果存在矛盾。需要进行大规模随机前瞻性试验来评估雄激素在男性心血管疾病中的特定功能，以便得出更好的结论。
