短期睾酮替代疗法可改善性欲和身体成分。
Short term testosterone replacement therapy improves libido and body composition.
作者信息
Andrade Edésio Seara de, Clapauch Ruth, Buksman Salo
机构信息
Divisão de Endocrinologia Feminina e Andrologia, Setor de Endocrinologia, Hospital da Lagoa, Rio de Janeiro, RJ, Brasil.
出版信息
Arq Bras Endocrinol Metabol. 2009 Nov;53(8):996-1004. doi: 10.1590/s0004-27302009000800014.
OBJECTIVE
To assess the efficacy and safety of testosterone replacement in males with late-onset hypogonadism compared to hypogonadal men without replacement, and controls, during six months.
METHODS
We assessed, through ADAM, AMS, IIEF-5 and SF-36 questionnaires, and through clinical and laboratory examinations, 62 patients divided into three groups: 17 hypogonadal males (HR) used intramuscular testosterone every three weeks; 14 hypogonadal males (HV) and 31 non-hypogonadal males (CV) used oral vitamins daily.
RESULTS
When compared to others, HR group obtained libido improvement assessed by ADAM 1 (p = 0.004), and borderline sexual potency improvement assessed by IIEF-5 (p = 0.053), besides a decrease in waist circumference after eight weeks (p = 0.018). The remaining parameters did not differ between the groups. PSA and hematocrit remained stable in those using testosterone.
CONCLUSION
Six months of testosterone replacement improved sexuality and body composition, with prostatic and hematological safety.
目的
评估与未接受替代治疗的性腺功能减退男性及对照组相比，睾酮替代疗法对迟发性性腺功能减退男性患者六个月的疗效和安全性。
方法
我们通过ADAM、AMS、IIEF - 5和SF - 36问卷以及临床和实验室检查，对62例患者进行了评估，这些患者分为三组：17例性腺功能减退男性（HR组）每三周接受一次肌肉注射睾酮；14例性腺功能减退男性（HV组）和31例非性腺功能减退男性（CV组）每天服用口服维生素。
结果
与其他组相比，HR组在ADAM 1评估中性欲得到改善（p = 0.004），在IIEF - 5评估中性功能有临界性改善（p = 0.053），此外八周后腰围减小（p = 0.018）。其余参数在各组之间无差异。使用睾酮的患者前列腺特异性抗原（PSA）和血细胞比容保持稳定。
结论
六个月的睾酮替代疗法改善了性功能和身体组成，且具有前列腺和血液学安全性。
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