161 例有症状的迟发性性腺功能减退症男性患者采用长效注射用十一酸睾酮治疗：对身体成分、脂类和性心理抱怨的影响。

Treatment of 161 men with symptomatic late onset hypogonadism with long-acting parenteral testosterone undecanoate: effects on body composition, lipids, and psychosexual complaints.

机构信息

Division of Urology, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

出版信息

J Sex Med. 2010 Nov;7(11):3765-74. doi: 10.1111/j.1743-6109.2010.01994.x. Epub 2010 Aug 30.

DOI:10.1111/j.1743-6109.2010.01994.x

PMID:20807330

Abstract

INTRODUCTION

Elderly men may suffer from late-onset hypogonadism (LOH). The long-term effects of long-acting testosterone undecanoate (TU) in a large number of LOH men have not yet been reported. Aims. We analyzed the effects of normalization of plasma testosterone (T) in LOH men.

METHODS

The records of 161 men with LOH (baseline T<300 ng/dL) were reviewed and 100 men had used parenteral TU for >12 months. The mean duration of treatment was 90.6 weeks (54 to 150 weeks).

MAIN OUTCOME MEASURES

Body mass index (BMI), waist circumference, percentage body fat, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, prostate-specific antigen (PSA), and hematocrit were measured. Further the Aging Male Symptoms' scale (AMS) and the International Index of Erectile Function (IIEF-5 and 15) were scored.

RESULTS

T therapy was associated with a significant decline in waist circumference (P=0.028) and percentage body fat (P<0.001), but no change of BMI. Total cholesterol and LDL cholesterol declined significantly (P=0.005 and P=0.024, respectively), with no significant changes of HDL cholesterol and triglycerides. The scores of sub-scales of AMS (psychological, somotovegetative and sexual factors) decreased (P=0.044, P=0.200 and P=0.071, respectively). The mean IIEF-5 (P=0.011) and IIEF-15 scores (P=0.021) improved significantly. Erectile function domain, orgasmic function domain, sexual desire domain, intercourse satisfaction domain, and overall satisfaction domain improved. Median PSA rose from 0.95 (0.640; 1.558) ng/mL to 1.480 (1.015; 2.275) ng/mL (P<0.001), with 11 patients >4 ng/mL (4.01-13.21). On biopsy there was no evidence for malignancy. The mean hematocrit level increased significantly from 42.3±3.4% to 47.1±3.8%.

CONCLUSIONS

Normalizing serum T in men with LOH resulted in improvement of the metabolic syndrome, mood and sexual functions and appeared acceptably safe.

摘要

简介

老年男性可能患有迟发性性腺功能减退症（LOH）。目前尚未报道大量 LOH 男性长期使用长效十一酸睾酮（TU）的影响。目的：我们分析了 LOH 男性血浆睾酮（T）正常化的效果。

方法

回顾了 161 名 LOH 男性（基础 T<300ng/dL）的记录，其中 100 名男性使用了注射用 TU 治疗>12 个月。平均治疗时间为 90.6 周（54 至 150 周）。

主要观察指标

体重指数（BMI）、腰围、体脂百分比、总胆固醇、高密度脂蛋白（HDL）胆固醇、低密度脂蛋白（LDL）胆固醇、甘油三酯、前列腺特异性抗原（PSA）和红细胞比容。进一步评估男性衰老症状评分（AMS）和国际勃起功能指数（IIEF-5 和 15）评分。

结果

T 治疗与腰围（P=0.028）和体脂百分比（P<0.001）显著下降相关，但 BMI 无变化。总胆固醇和 LDL 胆固醇显著下降（P=0.005 和 P=0.024），HDL 胆固醇和甘油三酯无明显变化。AMS 亚量表评分（心理、躯体植物神经和性功能因素）下降（P=0.044、P=0.200 和 P=0.071）。平均 IIEF-5（P=0.011）和 IIEF-15 评分（P=0.021）显著提高。勃起功能、性高潮功能、性欲、性交满意度和总体满意度改善。中位 PSA 从 0.95（0.640；1.558）ng/mL 升至 1.480（1.015；2.275）ng/mL（P<0.001），11 例患者>4ng/mL（4.01-13.21）。前列腺活检未见恶性证据。平均红细胞比容水平从 42.3±3.4%显著升高至 47.1±3.8%。