Department of Internal Medicine, Unit of Geriatrics and Internal Medicine, CHU Nancy, Vandoeuvre-les-Nancy, France.
J Nutr Health Aging. 2010 Feb;14(2):161-6. doi: 10.1007/s12603-009-0188-5.
Since few studies have investigated Health related Quality of Life (HRQoL) in older patients with atrial fibrillation, the aim of this cross-sectional study was to compare HRQoL in AF elderly inpatients of 65 and more with that of age-matched controlled subjects.
HRQoL was assessed with two generic HRQoL instruments: the MOS-SF 36, a largely recognized instrument, and the Duke Health Profile.
Nancy University Hospital patients presenting with atrial fibrillation and three controls per patient free of cardiac arrhythmias, matched by age, sex and hospital department to atrial fibrillation patients.
Forty one atrial fibrillation patients and 123 controls were included. Both groups were comparable for associated disorders, other than coronary artery disease and chronic respiratory failure. After adjustment, scores among atrial fibrillation patients were lower than among controls in 8 of 10 Duke and 6 of 8 SF-36 subscales. In terms of Quality of Life, meaningful differences (>or= 5 points) were recorded in the Duke: Mental, Depression, Anxiety, General Score; and in the SF-36: Physical functioning, Role emotional, Social functioning and Vitality. Nevertheless statistically significant differences were only observed for the Duke Mental (p=0.01), Depression (p=0.003) and Anxiety (p=0.03) scores.
In our study HRQoL measured in elderly inpatients with atrial fibrillation as compared with matched controlled was mainly altered in the "psychological" domains of the Duke Health Profile. From the patient's point of view, atrial fibrillation appears to have more mental than physical consequences. This study pointed out the utility to assess HRQoL in the management and treatment of elderly hospitalised atrial fibrillation patients.
由于很少有研究调查老年心房颤动患者的健康相关生活质量（HRQoL），本横断面研究的目的是比较 65 岁及以上心房颤动老年住院患者与年龄匹配的对照组的 HRQoL。
使用两种通用的 HRQoL 工具评估 HRQoL：MOS-SF 36，一种广泛认可的工具和杜克健康状况问卷。
南希大学医院因心房颤动就诊的患者，每个患者有 3 名对照，按年龄、性别和医院科室与心房颤动患者匹配，无心律失常。
共纳入 41 例心房颤动患者和 123 例对照。两组在除冠状动脉疾病和慢性呼吸衰竭以外的合并症方面具有可比性。调整后，在 10 个杜克量表和 8 个 SF-36 量表中的 8 个亚量表中，心房颤动患者的评分低于对照组。在生活质量方面，在杜克量表中记录到了有意义的差异（>或= 5 分）：心理、抑郁、焦虑、一般评分；在 SF-36 中：生理功能、角色情感、社会功能和活力。然而，仅在杜克量表的心理（p=0.01）、抑郁（p=0.003）和焦虑（p=0.03）得分上观察到统计学显著差异。
在我们的研究中，与匹配的对照组相比，老年心房颤动住院患者的 HRQoL 主要在杜克健康状况问卷的“心理”领域发生改变。从患者的角度来看，心房颤动似乎更多地影响心理健康，而不是身体健康。本研究指出评估老年住院心房颤动患者 HRQoL 的实用性。
