Naganuma Y, Konishi T, Murakami M, Hongou K, Yamatani M, Okada T
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
No To Hattatsu. 1991 Mar;23(2):194-9.
Auditory event-related potentials (ERPs) were recorded from 53 neurologically normal children of 5 to 15 years of age, and 8 healthy adults. To clarify the developmental changes and to obtain a normative value in childhood, the latency and amplitude of ERPs (N100, P200, N200, and P300) were examined. ERPs were elicited with the auditory oddball paradigm. P300 components were detected in all subjects. A strong positive correlation was demonstrated between latencies of two trials, and a small latency difference between trials was interpreted as being clinically unimportant. A significant negative correlation was observed between P300 latency and age during childhood (latency (msec) = -9.81 X (Age) + 459: r = 0.75, p less than 0.01). A mild negative correlation was also observed between N100, P200 and N200 latency and age. P300-topography of amplitude showed various patterns in young childhood, but in adolescence a maximum point was Pz in almost all subjects. These findings suggest that auditory ERPs can be easily measured in childhood and are useful for objective evaluation of the cognitive function.
对53名5至15岁神经功能正常的儿童以及8名健康成年人记录了听觉事件相关电位（ERP）。为了阐明发育变化并获得儿童期的正常参考值，对ERP（N100、P200、N200和P300）的潜伏期和波幅进行了检测。采用听觉Oddball范式诱发ERP。在所有受试者中均检测到P300成分。两次试验的潜伏期之间显示出强正相关，试验间潜伏期的微小差异被认为在临床上不重要。儿童期P300潜伏期与年龄之间观察到显著负相关（潜伏期（毫秒）=-9.81×（年龄）+459：r=0.75，p<0.01）。N100、P200和N200潜伏期与年龄之间也观察到轻度负相关。P300波幅的地形图在幼儿期呈现出各种模式，但在青少年期，几乎所有受试者的最大波幅点均位于头顶中央（Pz）。这些发现表明，听觉ERP在儿童期易于测量，并且有助于对认知功能进行客观评估。
