Naganuma Y, Konishi T, Hongou K, Murakami M, Yamatani M, Okada T
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
No To Hattatsu. 1991 May;23(3):259-64.
Auditory event-related potentials (ERPs) were recorded from 129 epileptic children of 5 to 20 years of age. To clarify the developmental changes in each of the epileptic syndromes, P300 latencies of ERPs were examined. ERPs were elicited with the auditory oddball paradigm. P300 detection was occasionally difficult in epileptic children. Mean P300 latency in epileptic children (375 +/- 39.7 msec) was significantly prolonged compared with that in normal control children. (355 +/- 39.1 msec). P300 latencies in the children with symptomatic partial epilepsies were prolonged and were not recognized to be shortened with age. In the idiopathic partial epilepsies of 5 to 12 years of age, P300 latencies showed almost the same values with those in the normal children. However, in the idiopathic partial epilepsies of 13 to 15 years of age, P300 latencies were significantly prolonged compared with those in normal children and there were no difference in P300 latencies with other epileptic syndromes. P300 latencies in idiopathic generalized epilepsies showed intermediate values between that in symptomatic partial epilepsies and idiopathic partial epilepsies. Each epileptic syndrome showed different developments in P300 latencies with age. This results suggests that the development and the disturbance of cognitive functions differ among the epileptic syndromes.
对129名5至20岁的癫痫儿童进行了听觉事件相关电位（ERP）记录。为了阐明每种癫痫综合征的发育变化，对ERP的P300潜伏期进行了检查。采用听觉oddball范式诱发ERP。在癫痫儿童中，P300的检测有时很困难。癫痫儿童的平均P300潜伏期（375±39.7毫秒）与正常对照儿童相比显著延长（355±39.1毫秒）。症状性部分性癫痫患儿的P300潜伏期延长，且未发现随年龄缩短。在5至12岁的特发性部分性癫痫中，P300潜伏期与正常儿童几乎相同。然而，在13至15岁的特发性部分性癫痫中，P300潜伏期与正常儿童相比显著延长，且与其他癫痫综合征的P300潜伏期无差异。特发性全身性癫痫的P300潜伏期在症状性部分性癫痫和特发性部分性癫痫之间呈现中间值。每种癫痫综合征的P300潜伏期随年龄呈现不同的发展。这一结果表明，癫痫综合征之间认知功能的发育和障碍存在差异。
