Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, PO Box 80154, 3508 TD Utrecht, The Netherlands.
Eur Spine J. 2010 Aug;19(8):1325-9. doi: 10.1007/s00586-010-1280-6. Epub 2010 Feb 2.
Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic disorder of the axial and peripheral skeleton in humans and has incidentally been described in dogs. The aims of this retrospective radiographic cohort study were to determine the prevalence of DISH in an outpatient population of skeletally mature dogs and to investigate if dogs can be used as an animal model for DISH. The overall prevalence of canine DISH was 3.8% (78/2041). The prevalence of DISH increased with age and was more frequent in male dogs, similar to findings in human studies. In the Boxer breed the prevalence of DISH was 40.6% (28/69). Dog breeds represent closed gene pools with a high degree of familiar relationship and the high prevalence in the Boxer may be indicative of a genetic origin of DISH. It is concluded that the Boxer breed may serve as an animal model for DISH in humans.
弥漫特发性骨肥厚（DISH）是人类中轴和周围骨骼的一种全身性疾病，在犬中也有偶然描述。本回顾性放射学队列研究的目的是确定 DISH 在骨骼成熟犬的门诊人群中的流行率，并研究犬是否可作为 DISH 的动物模型。犬 DISH 的总体流行率为 3.8%（78/2041）。DISH 的流行率随年龄增长而增加，且在雄性犬中更为常见，与人类研究的发现相似。在拳师犬中，DISH 的流行率为 40.6%（28/69）。犬种代表了具有高度近亲关系的封闭基因库，拳师犬中的高流行率可能表明 DISH 具有遗传起源。因此，可以得出结论，拳师犬可能是人类 DISH 的动物模型。
