Adult Spine Orthopaedics Department, Poznan University of Medical Sciences, 61-545 Poznan, Poland.
Int J Mol Sci. 2021 Apr 20;22(8):4255. doi: 10.3390/ijms22084255.
Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by the calcification and ossification of the ligaments of the cervical spine; in some cases, it may result in dysphagia. The condition is more common in men over 50 years of age with metabolic disorders, and it is often asymptomatic and not a major issue for patients. The etiology of DISH is poorly understood, and known genetic factors indicate multiple signal pathways and multigene inheritance. In this review, we discuss the epidemiological, clinical, and etiological aspects of DISH with a special focus on dysphagia.
弥漫特发性骨肥厚（DISH）是一种以颈椎韧带的钙化和骨化为特征的疾病；在某些情况下，它可能导致吞咽困难。该疾病在 50 岁以上有代谢紊乱的男性中更为常见，通常无症状，对患者也不是大问题。DISH 的病因尚不清楚，已知的遗传因素表明存在多个信号通路和多基因遗传。在这篇综述中，我们讨论了 DISH 的流行病学、临床和病因学方面，特别关注了吞咽困难。
