An Howard S, Masuda Koichi
Department of Orthopaedic Surgery, Rush Medical College, 1725 West Harrison Street, Suite 1063, Chicago, IL 60612, USA.
J Bone Joint Surg Am. 2006 Apr;88 Suppl 2:88-94. doi: 10.2106/JBJS.E.01272.
Models available for the study of intervertebral disc degeneration are designed to answer many important questions. In vitro biologic models employ a variety of cell, tissue, or organ culture techniques with culture conditions that partially mimic the cellular environment of the degenerated human intervertebral disc. In vitro biomechanical models include intervertebral disc or motion-segment loading experiments as well as finite element modeling techniques. The literature describes numerous in vivo animal models for use in the study of intervertebral disc degeneration, each of which has its own advantages and disadvantages. Human-subject studies have included the use of magnetic resonance imaging and other techniques to assess diffusion into the intervertebral disc, to measure intradiscal pressure, to conduct kinematic or stiffness studies of lumbar motion segments, and to evaluate muscular forces on the spine. Although all of these studies are helpful in answering specific questions, their relevance in assessing disc degeneration in patients with symptoms of discogenic pain must be carefully considered.
可用于研究椎间盘退变的模型旨在回答许多重要问题。体外生物学模型采用各种细胞、组织或器官培养技术，其培养条件部分模拟了退变的人类椎间盘的细胞环境。体外生物力学模型包括椎间盘或运动节段加载实验以及有限元建模技术。文献中描述了许多用于研究椎间盘退变的体内动物模型，每种模型都有其自身的优缺点。人体研究包括使用磁共振成像和其他技术来评估椎间盘内的扩散、测量椎间盘内压力、进行腰椎运动节段的运动学或刚度研究以及评估脊柱上的肌肉力量。尽管所有这些研究都有助于回答特定问题，但在评估有椎间盘源性疼痛症状的患者的椎间盘退变时，必须仔细考虑它们的相关性。
