Liu Huanran, Liu Ge, Bao Quan, Sun Wei, Bao Haidong, Bi Liang, Wen Wei, Liu Yanfeng, Wang Zhenglin, Yin Xunguo, Bai Yunqing, Hu Xiang
Department of General Surgery, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China.
J Gastrointest Cancer. 2010 Jun;41(2):116-20. doi: 10.1007/s12029-009-9125-4.
In cancer patients, the balance between neutrophil (N) and lymphocyte (L) cell counts fluctuates with advancing disease. The objective of our study was to determine the prognostic implications of the N/L ratio in the peripheral blood of rectal cancer patients.
Study participants were identified from a prospective cohort of patients with rectal cancer in Dalian of China (n = 123).
The median baseline N/L ratio was 2.41 +/- 2.206 (range, 0.76-20.45). Our results revealed that the N/L ratio was significantly associated with tumor size (P = 0.003) and level of cancer antigen 125 (P = 0.027). A multivariate Cox model established a significant relationship between the N/L ratio and survival (adjusted hazard ratio, 2.615; 95% confidence interval, 1.152-5.933; P = 0.021).
These results suggest that the N/L ratio is an independent prognostic factor in rectal cancer, and the N/L ratio may serve as a clinically accessible and useful biomarker for patient survival.
在癌症患者中，中性粒细胞（N）与淋巴细胞（L）计数之间的平衡会随着疾病进展而波动。我们研究的目的是确定直肠癌患者外周血中N/L比值的预后意义。
研究参与者来自中国大连的直肠癌患者前瞻性队列（n = 123）。
基线N/L比值的中位数为2.41±2.206（范围为0.76 - 20.45）。我们的结果显示，N/L比值与肿瘤大小（P = 0.003）和癌抗原125水平（P = 0.027）显著相关。多变量Cox模型确定了N/L比值与生存率之间的显著关系（调整后的风险比为2.615；95%置信区间为1.152 - 5.933；P = 0.021）。
这些结果表明，N/L比值是直肠癌的一个独立预后因素，并且N/L比值可能作为一种临床上可获取且有用的患者生存生物标志物。
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