Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan; Department of Surgery, Tagawa Municipal Hospital, Fukuoka, Japan.
Department of Surgery, Matsuyama Red Cross Hospital, Ehime, Japan.
J Surg Res. 2020 Jan;245:281-287. doi: 10.1016/j.jss.2019.07.072. Epub 2019 Aug 14.
Systemic inflammation and immune response play crucial roles in tumor growth; neutrophil-to-lymphocyte ratio (NLR) is a known systemic inflammatory scoring system. Previous studies have reported that NLR is a prognostic biomarker in various human cancers. The aim of this study was to determine whether the NLR predicts tumor recurrence in patients with stage I-II rectal cancer after curative resection.
We retrospectively analyzed 130 consecutive patients with stage I-II rectal cancer who underwent curative resection between January 2006 and March 2015 at our institution without any preoperative treatment. We investigated whether clinicopathologic factors including NLR were associated with cancer recurrence after curative surgery.
There were four cases (3.1%) of cancer-specific deaths and 16 cases (12.3%) of recurrence; the 5-year disease-free survival rate was 85.6%. NLR, pathologic T-category, and lymphatic invasion were significantly associated with disease-free survival. Multivariate analysis further showed that these three factors were independently associated with disease-free survival.
Preoperative NLR could predict tumor relapse in stage I-II rectal cancer and might be a useful biomarker for predicting recurrence in patients undergoing curative resection.
系统性炎症和免疫反应在肿瘤生长中起着至关重要的作用；中性粒细胞与淋巴细胞比值（NLR）是一种已知的全身性炎症评分系统。先前的研究报告称，NLR 是各种人类癌症的预后生物标志物。本研究旨在确定 NLR 是否可预测接受根治性切除术的 I 期- II 期直肠癌患者的肿瘤复发。
我们回顾性分析了 2006 年 1 月至 2015 年 3 月期间在我院接受根治性切除术且未接受任何术前治疗的 130 例连续 I 期- II 期直肠癌患者。我们调查了包括 NLR 在内的临床病理因素是否与根治术后癌症复发有关。
有 4 例（3.1%）癌症特异性死亡和 16 例（12.3%）复发；5 年无病生存率为 85.6%。NLR、病理 T 分期和淋巴浸润与无病生存率显著相关。多因素分析进一步表明，这三个因素与无病生存率独立相关。
术前 NLR 可预测 I 期- II 期直肠癌的肿瘤复发，可能是预测接受根治性切除术患者复发的有用生物标志物。
