炎症与癌症。
Inflammation and cancer.
作者信息
Coussens Lisa M, Werb Zena
机构信息
Cancer Research Institute, Department of Pathology, University of California, San Francisco, California 94143, USA.
出版信息
Nature. 2002;420(6917):860-7. doi: 10.1038/nature01322.
Abstract
Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new anti-inflammatory therapeutic approaches to cancer development.
摘要
近期数据拓展了炎症是肿瘤进展关键组成部分这一概念。许多癌症起源于感染、慢性刺激和炎症部位。现在越来越清楚的是，肿瘤微环境在很大程度上由炎症细胞调控，是肿瘤形成过程中不可或缺的参与者，促进肿瘤细胞的增殖、存活和迁移。此外，肿瘤细胞还利用了天然免疫系统的一些信号分子，如选择素、趋化因子及其受体来进行侵袭、迁移和转移。这些见解正在推动针对癌症发展的新抗炎治疗方法。
相似文献
1
Inflammation and cancer.炎症与癌症。
Nature. 2002;420(6917):860-7. doi: 10.1038/nature01322.
2
The chemokine system in cancer biology and therapy.癌症生物学和治疗中的趋化因子系统。
Cytokine Growth Factor Rev. 2010 Feb;21(1):27-39. doi: 10.1016/j.cytogfr.2009.11.007. Epub 2009 Dec 8.
3
Proprotein convertases: Key players in inflammation-related malignancies and metastasis.蛋白转化酶：炎症相关恶性肿瘤和转移的关键因素。
Cancer Lett. 2020 Mar 31;473:50-61. doi: 10.1016/j.canlet.2019.12.027. Epub 2019 Dec 30.
4
Inflammatory chemokines in cancer growth and progression.炎症趋化因子在癌症生长和进展中的作用
Eur J Cancer. 2006 Apr;42(6):760-7. doi: 10.1016/j.ejca.2006.01.002. Epub 2006 Feb 28.
5
Targeting inflammation in cancer therapy: from mechanistic insights to emerging therapeutic approaches.癌症治疗中的炎症靶向：从机制洞察到新兴治疗方法
J Transl Med. 2025 May 26;23(1):588. doi: 10.1186/s12967-025-06583-3.
6
Inflammation in epithelial skin tumours: old stories and new ideas.上皮性皮肤肿瘤中的炎症：旧闻与新观点
Eur J Cancer. 2006 Apr;42(6):735-44. doi: 10.1016/j.ejca.2006.01.014. Epub 2006 Mar 9.
7
Neutralizing tumor-promoting chronic inflammation: a magic bullet?中和促肿瘤慢性炎症：灵丹妙药？
Science. 2013 Jan 18;339(6117):286-91. doi: 10.1126/science.1232227.
8
Inflammation fires up cancer metastasis.炎症会引发癌症转移。
Semin Cancer Biol. 2017 Dec;47:170-176. doi: 10.1016/j.semcancer.2017.08.006. Epub 2017 Aug 31.
9
Acetamides: chemotherapeutic agents for inflammation-associated cancers.乙酰胺类：用于炎症相关癌症的化疗药物。
J Chemother. 2016 Aug;28(4):255-65. doi: 10.1179/1973947815Y.0000000060.
10
Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression.驱动炎症肿瘤微环境、肿瘤异质性和转移进展的机制。
Semin Cancer Biol. 2017 Dec;47:185-195. doi: 10.1016/j.semcancer.2017.08.001. Epub 2017 Aug 3.
引用本文的文献
1
Potential Role of Oral Microbiota in Medication-Related Osteonecrosis of the Jaw in Cancer Patients: A Narrative Review.口腔微生物群在癌症患者颌骨药物相关性骨坏死中的潜在作用：一项叙述性综述
Cureus. 2025 Aug 12;17(8):e89943. doi: 10.7759/cureus.89943. eCollection 2025 Aug.
2
Development and validation of a serum inflammatory biomarker-driven machine-learning model for prognostic stratification in surgical limited-stage small cell lung cancer.血清炎症生物标志物驱动的机器学习模型在手术局限期小细胞肺癌预后分层中的开发与验证
Transl Lung Cancer Res. 2025 Aug 31;14(8):2983-2995. doi: 10.21037/tlcr-2025-182. Epub 2025 Aug 14.
3
Angiogenesis-related gene NID2 profiling and immune infiltration in bladder cancer: prognostic implications and immunotherapy response.血管生成相关基因NID2在膀胱癌中的特征分析及免疫浸润：预后意义和免疫治疗反应
Front Immunol. 2025 Aug 29;16:1615173. doi: 10.3389/fimmu.2025.1615173. eCollection 2025.
4
Neutrophil to Lymphocyte Ratio a Prognostic Tool in Endometrial Cancer Among Classical Prognostic Factors.在经典预后因素中，中性粒细胞与淋巴细胞比值作为子宫内膜癌的一种预后工具。
Diagnostics (Basel). 2025 Aug 27;15(17):2172. doi: 10.3390/diagnostics15172172.
5
Prognostic Significance and Emerging Predictive Potential of Interleukin-1β Expression in Oncogene-Driven NSCLC.白细胞介素-1β表达在癌基因驱动的非小细胞肺癌中的预后意义及新兴预测潜力
Cancers (Basel). 2025 Sep 3;17(17):2895. doi: 10.3390/cancers17172895.
6
Curcumin, an active component of turmeric: biological activities, nutritional aspects, immunological, bioavailability, and human health benefits - a comprehensive review.姜黄素，姜黄的一种活性成分：生物学活性、营养特性、免疫学、生物利用度及对人类健康的益处——综述
Front Immunol. 2025 Aug 21;16:1603018. doi: 10.3389/fimmu.2025.1603018. eCollection 2025.
7
Regulation mechanism of curcumin mediated inflammatory pathway and its clinical application: a review.姜黄素介导的炎症通路调控机制及其临床应用：综述
Front Pharmacol. 2025 Aug 20;16:1642248. doi: 10.3389/fphar.2025.1642248. eCollection 2025.
8
Advancing health psychology research in oncology: Biobehavioral models, stress pathways, and stress-management interventions for cancer patients.推进肿瘤学中的健康心理学研究：癌症患者的生物行为模型、应激途径及应激管理干预措施
Int J Clin Health Psychol. 2025 Jul-Sep;25(3):100615. doi: 10.1016/j.ijchp.2025.100615. Epub 2025 Aug 15.
9
Mendelian randomization analysis reveals causal roles of inflammatory cytokines in thyroid cancer pathogenesis.孟德尔随机化分析揭示炎症细胞因子在甲状腺癌发病机制中的因果作用。
Discov Oncol. 2025 Sep 2;16(1):1671. doi: 10.1007/s12672-025-03533-9.
10
The association between neighborhood socioeconomic status and breast cancer incidence and mortality risk: a large-scale cohort studies systematic review and meta-analysis.社区社会经济地位与乳腺癌发病率和死亡率风险之间的关联：一项大规模队列研究的系统评价和荟萃分析。
Breast Cancer. 2025 Aug 30. doi: 10.1007/s12282-025-01764-w.
本文引用的文献
1
THE EXPERIMENTAL DISCLOSURE OF LATENT NEOPLASTIC CHANGES IN TARRED SKIN.焦油皮肤潜伏性肿瘤变化的实验揭示。
J Exp Med. 1941 Feb 28;73(3):391-416. doi: 10.1084/jem.73.3.391.
2
CONDITIONAL NEOPLASMS AND SUBTHRESHOLD NEOPLASTIC STATES : A STUDY OF THE TAR TUMORS OF RABBITS.条件性肿瘤和阈下肿瘤状态：对家兔焦油肿瘤的研究。
J Exp Med. 1941 Feb 28;73(3):365-90. doi: 10.1084/jem.73.3.365.
3
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.SHP2和STAT介导的三叶因子基因激活在gp130突变小鼠中对胃肠道稳态的相互调节
Nat Med. 2002 Oct;8(10):1089-97. doi: 10.1038/nm763. Epub 2002 Sep 9.
4
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis.肿瘤相关巨噬细胞表达淋巴管内皮生长因子，并与肿瘤周围淋巴管生成有关。
Am J Pathol. 2002 Sep;161(3):947-56. doi: 10.1016/S0002-9440(10)64255-1.
5
Strategies for MMP inhibition in cancer: innovations for the post-trial era.癌症中基质金属蛋白酶抑制策略：试验后时代的创新
Nat Rev Cancer. 2002 Sep;2(9):657-72. doi: 10.1038/nrc884.
6
Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation.丙型肝炎病毒核心蛋白对STAT3的激活会导致细胞转化。
J Exp Med. 2002 Sep 2;196(5):641-53. doi: 10.1084/jem.20012127.
7
Macrophages as effector cells in interleukin 12-induced T cell-dependent tumor rejection.巨噬细胞作为白细胞介素12诱导的T细胞依赖性肿瘤排斥反应中的效应细胞。
Cancer Res. 2002 Sep 1;62(17):5069-75.
8
Tumor necrosis factor-alpha blockade: a novel therapy for rheumatic disease.肿瘤坏死因子-α阻断：一种治疗风湿性疾病的新疗法。
Clin Immunol. 2002 Jun;103(3 Pt 1):231-42. doi: 10.1006/clim.2002.5191.
9
10
Regional analysis of p53 mutations in rheumatoid arthritis synovium.类风湿性关节炎滑膜中p53突变的区域分析
Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10025-30. doi: 10.1073/pnas.152333199. Epub 2002 Jul 15.
Zotero 插件