Coussens Lisa M, Werb Zena
Cancer Research Institute, Department of Pathology, University of California, San Francisco, California 94143, USA.
Nature. 2002;420(6917):860-7. doi: 10.1038/nature01322.
Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new anti-inflammatory therapeutic approaches to cancer development.
近期数据拓展了炎症是肿瘤进展关键组成部分这一概念。许多癌症起源于感染、慢性刺激和炎症部位。现在越来越清楚的是,肿瘤微环境在很大程度上由炎症细胞调控,是肿瘤形成过程中不可或缺的参与者,促进肿瘤细胞的增殖、存活和迁移。此外,肿瘤细胞还利用了天然免疫系统的一些信号分子,如选择素、趋化因子及其受体来进行侵袭、迁移和转移。这些见解正在推动针对癌症发展的新抗炎治疗方法。