韩国猪传染性胃肠炎病毒的检测和分子特征分析。
Detection and molecular characterization of porcine toroviruses in Korea.
机构信息
Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea.
出版信息
Arch Virol. 2010 Mar;155(3):417-22. doi: 10.1007/s00705-010-0595-2. Epub 2010 Feb 3.
This study examined the prevalence and genetic diversity of the porcine torovirus (PToV) in Korea. Of 295 samples, 19 (6.4%) samples tested positive for PToVs by RT-PCR. A low nucleotide sequence identity of the partial S gene was detected among the Korean PToVs (73.5%) and between the Korean and European PToVs (74.0%). Phylogenetic analysis of the spike and nucleocapsid genes showed that the Korean PToVs form distinct branches with clusters corresponding to the farm of origin, which were separate from the other known foreign PToVs. These findings suggest that genetically diverse Korean PToV strains cause sporadic infections in Korea.
本研究调查了韩国猪传染性胃肠炎病毒（PToV）的流行情况和遗传多样性。通过 RT-PCR 检测，295 个样本中有 19 个（6.4%）样本呈 PToV 阳性。韩国 PToV 的部分 S 基因核苷酸序列同一性较低（73.5%），韩国和欧洲 PToV 之间的核苷酸序列同一性也较低（74.0%）。对刺突蛋白和核衣壳基因的系统进化分析表明，韩国 PToV 形成了与农场来源相对应的独特分支，与其他已知的外国 PToV 分离。这些发现表明，遗传多样的韩国 PToV 株在韩国引起散发性感染。
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