Department of Orthopaedic Surgery, Pontificia Universidad Catolica de Chile, Marcoleta 352, Santiago, Chile.
Eur Spine J. 2010 Jun;19(6):940-4. doi: 10.1007/s00586-010-1288-y. Epub 2010 Feb 3.
Spinal fusion is usually performed on patients who receive bisphosphonates (BP); however, limited data on their action on spinal fusion are available. Previous studies in animal models have shown that chronic administrations of BP reduced spinal fusion rates, and only one study has shown that a single dose administration of zolendronic acid increased fusion rate. The objective of the present study was to evaluate if pamidronate (PA), which was previously demonstrated to reduce spinal fusion rate when administered continuously for 8 weeks, would increase the spinal fusion rate if administered in a single dose at the time of surgery in a rabbit model. Thirty-two New Zealand rabbits underwent an L5-L6 posterolateral intertransverse fusion with iliac crest autograft. Animals were randomized to receive either PA 3 mg/kg in a single dose immediately after surgery, or normal saline. Animals were killed 8 weeks after surgery and fusion was determined by manual palpation and radiographic analysis. Fusion healing was obtained in eight rabbits (50%) in the PA group and in four animals (25%) in the control group, p = 0.137. In a rabbit model, a single dose of PA did not decrease lumbar spinal arthrodesis consolidation rates, but it obtained a nonsignificant higher spinal fusion rate.
脊柱融合术通常用于接受双膦酸盐 (BP) 治疗的患者；然而，关于它们对脊柱融合作用的有限数据。以前的动物模型研究表明，BP 的慢性给药会降低脊柱融合率，只有一项研究表明单次给予唑来膦酸会增加融合率。本研究的目的是评估帕米膦酸（PA）是否会增加脊柱融合率，如果在兔模型中手术时单次给予，先前的研究表明连续 8 周给药会降低脊柱融合率。32 只新西兰兔行 L5-L6 经后路横突间融合髂嵴自体骨移植。动物随机分为术后立即给予 PA 3mg/kg 单剂量或生理盐水。术后 8 周处死动物，通过手法触诊和放射学分析确定融合。PA 组有 8 只（50%）兔子融合愈合，对照组有 4 只（25%）兔子融合愈合，p = 0.137。在兔模型中，PA 单剂量并未降低腰椎脊柱融合固定率，但获得了非显著更高的脊柱融合率。
