Manitoba Institute of Cell Biology, CancerCare Manitoba, Department of Physiology, University of Manitoba, Winnipeg, Canada R3E 0V9.
J Cell Biochem. 2010 Apr 15;109(6):1095-102. doi: 10.1002/jcb.22501.
Telomeres are the ends of chromosomes and protect them from degradation and fusion. As such, their stability is required for normal cellular function. Telomere dysfunction is found often at the origin of cellular transformation and contributes to the onset of genomic instability, a hallmark of cancer cells. In this article, I discuss current data and concepts on telomere-mediated chromosomal rearrangements in cancer.
端粒是染色体的末端，可防止其降解和融合。因此，端粒的稳定性对于正常细胞功能至关重要。端粒功能障碍常发生在细胞转化的起始处，并导致基因组不稳定性的发生，这是癌细胞的一个标志。在本文中，我将讨论关于癌症中端粒介导的染色体重排的最新数据和概念。
