Urodynamic Urology Unit, Department of Urology, Medical School, University of Patras, Patras, Greece.
Neurourol Urodyn. 2010;29 Suppl 1:S46-50. doi: 10.1002/nau.20807.
To review if the existing data support the new concept that antimuscarinic agents can be used for the treatment of bladder outlet obstruction (BOO) with coexisting overactive bladder (OAB).
A literature search of Medline publications (up to 2008) on use of antimuscarinic agents for treatment BOO was performed and all data were presented. All relevant data from published studies in congress abstracts were as well included.
The existing data show that this treatment effectively improves patient quality of life. Concerns about the possibility of urinary retention were shown to be unfounded. It seems that antimuscarinic agents do not affect voiding pressures and the use of antimuscarinic agents for BOO seems safe.
The combination of an alpha-blocker and antimuscarinic agent for the treatment of BOO with concomitant OAB seems promising.
回顾现有数据是否支持抗毒蕈碱药物可用于治疗合并逼尿肌过度活动症（OAB）的膀胱出口梗阻（BOO）的新概念。
检索 Medline 出版物（截至 2008 年）中关于抗毒蕈碱药物治疗 BOO 的使用，并呈现所有数据。还包括大会摘要中发表研究的所有相关数据。
现有数据表明，这种治疗方法可有效改善患者的生活质量。关于发生尿潴留的可能性的担忧被证明是没有根据的。似乎抗毒蕈碱药物不会影响排尿压力，并且使用抗毒蕈碱药物治疗 BOO 似乎是安全的。
联合使用α-受体阻滞剂和抗毒蕈碱药物治疗合并 OAB 的 BOO 似乎很有前途。
