Department of Reproductive Medicine, University of California, San Diego, California, USA.
Neurourol Urodyn. 2010 Sep;29(7):1306-11. doi: 10.1002/nau.20836.
Determine whether urodynamic measures of urethral function [(valsalva leak point pressure (VLPP), maximum urethral closure pressure (MUCP), functional urethral length (FUL)] and the results of the supine empty bladder stress test (SEBST) correlate with each other and with subjective and objective measures of urinary incontinence (UI).
Data were collected preoperatively from subjects enrolled in a multicenter surgical trial of mid-urethral slings. Subjective measures included questionnaire scores from the Medical Epidemiological and Social Aspects of Aging Questionnaire, Urogenital Distress Inventory, and Incontinence Impact Questionnaire. Objective measures included a 24-hr pad weight test, incontinence episode frequency on a 3-day voiding diary, and a SEBST.
Five hundred ninety-seven women enrolled. Three hundred seventy-two women had valid VLPP values; 539 had valid MUCP/FUL values. Subjective measures of severity had weak to moderate correlation with each other (r = 0.25-0.43) and with objective measures of severity (r = -0.06 to 0.45). VLPP and MUCP had moderate correlation with each other (r = 0.36, P< 0.001). Urodynamic measures of urethral function had little or no correlation with subjective or objective measures of severity. Subjects with a positive SEBST had more subjective and objective severity measures compared to the negative SEBST group, but they did not have significantly different VLPP and MUCP values.
VLPP and MUCP have moderate correlation with each other, but each had little or no correlation with subjective or objective measures of severity or with the results of the SEBST. This data suggests that the urodynamic measures of urethral function are not related to subjective or objective measures of UI severity.
确定尿道功能的尿动力学测量指标(valsalva 漏点压(VLPP)、最大尿道闭合压(MUCP)、功能性尿道长度(FUL))与仰卧位空膀胱压力测试(SEBST)的结果之间是否相互关联,并与尿失禁(UI)的主观和客观测量指标相关。
本研究数据来自参加多中心尿道中段吊带手术试验的受试者的术前资料。主观测量指标包括老龄化医学流行病学和社会方面问卷、尿生殖窘迫问卷和尿失禁影响问卷的评分。客观测量指标包括 24 小时垫重试验、3 天排尿日记中的失禁发作频率和 SEBST。
共纳入 597 名女性。372 名女性有有效的 VLPP 值;539 名女性有有效的 MUCP/FUL 值。严重程度的主观测量指标之间存在弱到中度相关性(r=0.25-0.43),与严重程度的客观测量指标之间存在弱到中度相关性(r=-0.06 至 0.45)。VLPP 和 MUCP 之间具有中度相关性(r=0.36,P<0.001)。尿道功能的尿动力学测量指标与严重程度的主观或客观测量指标几乎没有相关性。SEBST 阳性的受试者与 SEBST 阴性的受试者相比,有更多的主观和客观严重程度测量指标,但他们的 VLPP 和 MUCP 值没有显著差异。
VLPP 和 MUCP 之间具有中度相关性,但彼此之间与严重程度的主观或客观测量指标或 SEBST 的结果几乎没有相关性。这些数据表明,尿道功能的尿动力学测量指标与 UI 严重程度的主观或客观测量指标无关。