Nager C W, Schulz J A, Stanton S L, Monga A
Department of Reproductive Medicine, University of California, San Diego Medical Center, 92103-8433, USA.
Int Urogynecol J Pelvic Floor Dysfunct. 2001;12(6):395-400. doi: 10.1007/s001920170020.
The aim of this study was to determine whether water perfusion maximum urethral closure pressure (MUCP) correlates with Valsalva leak-point pressure (LPP), and which of these best correlates with subjective and objective incontinence severity measures. Fifty-two women with previously diagnosed genuine stress incontinence (n = 46), or mixed incontinence with a minor and controlled urge component (n = 6), were assigned an incontinence status grade based on interview and diary review. These women then completed visually observed standing LPPs at 250 ml bladder capacity, supine water perfusion MUCP determinations, pad tests and quality of life questionnaires. The urodynamic and severity measures were compared with correlation analysis or analysis of variance. A modest correlation exists between LPP and MUCP (r = 0.50-0.62, P < 0.001). Both MUCP and LPP demonstrated significant decreases (P < 0.01) with increasing severity of assigned incontinence grade. A very low and insignificant correlation existed for these urodynamic parameters and pad loss or quality of life measures. MUCP and LPP correlate modestly with each other and both are comparable in predicting incontinence severity. Either can be used as the urodynamic measure to assess intrinsic sphincter deficiency.
本研究的目的是确定水灌注最大尿道闭合压（MUCP）是否与瓦尔萨尔瓦漏尿点压力（LPP）相关，以及这两者中哪一个与主观和客观尿失禁严重程度指标的相关性最佳。根据访谈和日记回顾，为52名先前被诊断为真性压力性尿失禁（n = 46）或伴有轻微且可控急迫性成分的混合性尿失禁（n = 6）的女性分配了尿失禁状态等级。然后，这些女性在膀胱容量为250 ml时完成了视觉观察下的站立位LPP测定、仰卧位水灌注MUCP测定、护垫试验和生活质量问卷。采用相关性分析或方差分析对尿动力学指标和严重程度指标进行比较。LPP与MUCP之间存在中等程度的相关性（r = 0.50 - 0.62，P < 0.001）。随着所分配尿失禁等级严重程度的增加，MUCP和LPP均显著降低（P < 0.01）。这些尿动力学参数与护垫漏尿量或生活质量指标之间存在非常低且无统计学意义的相关性。MUCP和LPP相互之间存在中等程度的相关性，并且在预测尿失禁严重程度方面具有可比性。两者均可作为评估内在括约肌缺陷的尿动力学指标。
