表观基因组如何影响精神疾病的发展。
How the epigenome contributes to the development of psychiatric disorders.
机构信息
Queensland Brain Institute, University of Queensland, Brisbane, QC 4072, Australia.
出版信息
Dev Psychobiol. 2010 May;52(4):331-42. doi: 10.1002/dev.20424.
Abstract
Epigenetics commonly refers to the developmental process by which cellular traits are established and inherited without a change in DNA sequence. These mechanisms of cellular memory also orchestrate gene expression in the adult brain and recent evidence suggests that the "epigenome" represents a critical interface between environmental signals, activation, repression and maintenance of genomic responses, and persistent behavior. We here review the current state of knowledge regarding the contribution of the epigenome toward the development of psychiatric disorders.
摘要
表观遗传学通常是指在不改变 DNA 序列的情况下建立和遗传细胞特征的发育过程。这些细胞记忆机制也在成年大脑中的基因表达中起作用，并且最近的证据表明，“表观基因组”代表了环境信号、基因组反应的激活、抑制和维持以及持久行为之间的关键界面。我们在这里回顾了关于表观基因组对精神疾病发展的贡献的现有知识状态。
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