Berger Shelley L, Kouzarides Tony, Shiekhattar Ramin, Shilatifard Ali
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Genes Dev. 2009 Apr 1;23(7):781-3. doi: 10.1101/gad.1787609.
A recent meeting (December 2008) regarding chromatin-based epigenetics was hosted by the Banbury Conference Center and Cold Spring Harbor Laboratory. The intent was to discuss aspects of epigenetic control of genomic function, and to arrive at a consensus definition of "epigenetics" to be considered by the broader community. It was evident that multiple mechanistic steps lead to the stable heritance of the epigenetic phenotype. Below we provide our view and interpretation of the proceedings at the meeting.
2008年12月,一场关于基于染色质的表观遗传学的会议在班伯里会议中心和冷泉港实验室举行。会议旨在讨论基因组功能表观遗传控制的各个方面,并就“表观遗传学”达成一个可供更广泛领域参考的共识定义。很明显,多个机制步骤导致了表观遗传表型的稳定遗传。以下是我们对会议议程的观点和解读。