Department of Gastroenterology, Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, B15 6HT, UK.
World J Gastroenterol. 2010 Feb 7;16(5):578-82. doi: 10.3748/wjg.v16.i5.578.
To assess patients' understanding for the reasons for taking 5-aminosalicylic acid or ursodeoxycholic acid as chemoprophylaxis against colorectal carcinoma associated with inflammatory bowel disease (IBD).
A questionnaire-based study using a 5-point opinion scale was performed. One hundred and ninety-two patients with colitis only and 74 patients with primary sclerosing cholangitis and IBD were invited to take part.
Overall response rate was 58%. Sixty-four percent of patients claimed full concordance with chemoprophylaxis for maintenance of remission. Eighty-four percent of patients considered daily concordance during remission to be very important. Seventy-five percent stated they understood the reasons for taking the drugs. However, only 50% of the patients were aware of any link of their condition to bowel cancer. Seventy-nine percent of patients felt their concordance and understanding would be improved if they were informed of the chemoprophylactic potential of the medication.
Despite good self-reported concordance, half of the patients were unaware of an association between colitis and bowel cancer. Explaining the potential chemoprophylactic benefits may enhance patients' overall concordance to 5-aminosalicylic acid and ursodeoxycholic acid and help maintain remission.
评估患者对服用 5-氨基水杨酸或熊去氧胆酸作为化学预防措施来预防与炎症性肠病（IBD）相关的结直肠癌的原因的理解。
采用 5 分制意见量表进行基于问卷调查的研究。邀请 192 名结肠炎患者和 74 名原发性硬化性胆管炎和 IBD 患者参与。
总体应答率为 58%。64%的患者声称完全同意化学预防以维持缓解。84%的患者认为在缓解期每天保持一致非常重要。75%的患者表示他们理解服用这些药物的原因。然而，只有 50%的患者知道他们的病情与肠癌有关。79%的患者认为，如果告知他们药物的化学预防潜力，他们的一致性和理解能力将会提高。
尽管自我报告的一致性良好，但仍有一半的患者不知道结肠炎与肠癌之间存在关联。解释潜在的化学预防益处可能会提高患者对 5-氨基水杨酸和熊去氧胆酸的整体一致性，并有助于维持缓解。
