Levine Jonathan S, Burakoff Robert
Center for Crohn's and Colitis, Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Inflamm Bowel Dis. 2007 Oct;13(10):1293-8. doi: 10.1002/ibd.20186.
Ulcerative colitis and Crohn's disease both confer an increased risk of developing colorectal cancer. The use of 5-aminosalicylate as a remission-inducing agent has been long accepted. Its use as a potential chemoprophylactic agent has been proposed and is used by some practitioners. This review examines the most recent data on 5-aminosalicylate as a chemoprophylactic drug as well as ursodeoxycholic acid, folic acid, azathioprine, and 6-mercaptopurine.
溃疡性结肠炎和克罗恩病都会增加患结直肠癌的风险。5-氨基水杨酸作为一种诱导缓解剂的使用早已被认可。有人提出将其用作潜在的化学预防剂，一些从业者也在使用。这篇综述考察了关于5-氨基水杨酸作为化学预防药物以及熊去氧胆酸、叶酸、硫唑嘌呤和6-巯基嘌呤的最新数据。
