Grassi Guido, Arenare Francesca, Dell'oro Raffaella, Quarti-Trevano Fosca, Brambilla Gianmaria, Carugo Stefano, Smith Michael, Mancia Giuseppe
Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università Milano-Bicocca, Ospedale San Gerardo, Monza, Milan.
Acta Cardiol. 2009 Dec;64(6):771-8. doi: 10.2143/AC.64.6.2044742.
Screening and educational campaigns on cardiovascular (CV) risk factors are important for primary and secondary prevention of CV disease. The CardioLab project is an observational cross-sectional study aimed at determining the prevalence of CV risk factors in a large unselected sample of the Italian population leaving in northern, central and southern Italy.
Data collection included family and clinical history, anthropometric data, blood pressure, blood glucose and total cholesterol values. Individual CV risk profile was assessed throughout by the risk charts of both the Progetto Cuore and the Score Project. In 36,161 participants (56.3% men) with a mean age of 60 years a complete assessment of the above mentioned variables was obtained. 44.4% of the screened subjects was overweight, while approximately 20% of the population displayed an obese state with a body mass index >30 kg/m2. Alterations in blood glucose levels indicating the presence of glucose intolerance were identified in 11.5% of the population while 9.3% displayed overt diabetes. 36.1% and 42.3% had elevated total cholesterol levels (> 200 mg/dl) and blood pressure values (> or = 140/90 mmHg), respectively. New diagnosis of diabetes, hypercholesterolaemia and hypertension was obtained in 5.3%, 23.6% and 19.6%, respectively. Global assessment of the CV risk showed that approximately 12.6% of the population is at a high risk of CV events over a 10-year period.
This large-scale observational study provides important information on the CV risk profile of an unselected Italian population and underlines the need for a more aggressive identification and appropriate correction of CV risk factors.
心血管（CV）危险因素的筛查和教育活动对于心血管疾病的一级和二级预防至关重要。CardioLab项目是一项观察性横断面研究，旨在确定居住在意大利北部、中部和南部的未经过筛选的大量意大利人群中CV危险因素的患病率。
数据收集包括家族史和临床病史、人体测量数据、血压、血糖和总胆固醇值。通过“心脏项目”和“评分项目”的风险图表对个体的CV风险状况进行全面评估。在36161名参与者（56.3%为男性）中，平均年龄为60岁，获得了上述变量的完整评估。44.4%的筛查对象超重，而约20%的人群体重指数>30kg/m²，处于肥胖状态。11.5%的人群被确定存在表明葡萄糖不耐受的血糖水平改变，而9.3%的人群患有显性糖尿病。总胆固醇水平升高（>200mg/dl）和血压值升高（≥140/90mmHg）的人群分别占36.1%和42.3%。新诊断出糖尿病、高胆固醇血症和高血压的比例分别为5.3%、23.6%和19.6%。CV风险的总体评估显示，约12.6%的人群在10年内发生CV事件的风险较高。
这项大规模观察性研究提供了关于未经过筛选的意大利人群CV风险状况的重要信息，并强调需要更积极地识别和适当纠正CV危险因素。
