Suzuki Kumiko, Inokuchi Akira, Miyazaki Junji, Kuratomi Yuichiro, Izuhara Kenji
Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Saga University, Saga, Japan.
Ann Otol Rhinol Laryngol. 2010 Jan;119(1):22-6. doi: 10.1177/000348941011900104.
Allergic rhinitis is known to be related to the Th2-type immune response, but no sensitive biomarker of severity yet exists. Serum squamous cell carcinoma antigen (SCCA) is clinically used as a popular tumor biomarker. We have demonstrated that SCCA is related to allergic diseases such as asthma. The purpose of the present study was to clarify the relationship between allergic rhinitis and SCCA, which had not yet been investigated.
We compared the serum SCCA levels in patients with allergic rhinitis due to Japanese cedar pollen and Dermatophagoides farinae with those in normal subjects. Thereafter, the correlations between the clinical severity of allergic rhinitis and the serum levels of SCCA were investigated. Furthermore, the influence of 8 variables (serum levels of SCCA, immunoglobulin E, eosinophil cationic protein, and eosinophils; age; gender; oral administration of antiallergic or antihistaminic agents; and use of nasal drops) in regard to the severity of allergic rhinitis was studied by a multiple regression analysis.
The SCCA levels of the D farinae group were statistically higher than those of the control group, and they correlated with the severity of rhinitis. Among the 8 variables, only the SCCA level was found to be a predictive factor of severity on a multiple regression analysis. No relationship between SCCA level and Japanese cedar pollen allergy was demonstrated.
These results suggest that the serum SCCA level may be a useful biomarker to evaluate the severity of allergic rhinitis caused by D farinae.
已知变应性鼻炎与Th2型免疫反应相关，但尚无敏感的严重程度生物标志物。血清鳞状细胞癌抗原（SCCA）在临床上用作一种常用的肿瘤生物标志物。我们已证明SCCA与哮喘等变应性疾病有关。本研究的目的是阐明变应性鼻炎与SCCA之间尚未被研究的关系。
我们比较了日本雪松花粉和粉尘螨引起的变应性鼻炎患者与正常受试者的血清SCCA水平。此后，研究了变应性鼻炎临床严重程度与血清SCCA水平之间的相关性。此外，通过多元回归分析研究了8个变量（血清SCCA、免疫球蛋白E、嗜酸性粒细胞阳离子蛋白和嗜酸性粒细胞水平；年龄；性别；口服抗过敏或抗组胺药；以及使用滴鼻剂）对变应性鼻炎严重程度的影响。
粉尘螨组的SCCA水平在统计学上高于对照组，且与鼻炎严重程度相关。在这8个变量中，多元回归分析显示只有SCCA水平是严重程度的预测因素。未证明SCCA水平与日本雪松花粉过敏之间存在关系。
这些结果表明，血清SCCA水平可能是评估粉尘螨引起的变应性鼻炎严重程度的有用生物标志物。
