用于筛查近期移民到意大利的潜伏性结核病的全血γ-干扰素释放试验（QFT-GIT）。
QuantiFERON-TB Gold In-Tube test (QFT-GIT) for the screening of latent tuberculosis in recent immigrants to Italy.
作者信息
Saracino Annalisa, Scotto Gaetano, Fornabaio Chiara, Martinelli Domenico, Faleo Giuseppina, Cibelli Donatella, Tartaglia Alessandra, Di Tullio Rocco, Fazio Vincenzina, Prato Rosa, Monno Laura, Angarano Gioacchino
机构信息
Clinic of Infectious Diseases, University of Foggia, Italy.
出版信息
New Microbiol. 2009 Oct;32(4):369-76.
To evaluate the agreement between QuantiFERON-TB Gold In-Tube test (QFT-GIT) and tuberculin skin test (TST) for the screening of latent tuberculosis infection (LTBI) in recent immigrants to Italy, 279 subjects were submitted to concomitant TST and QFT-GIT. The agreement was analyzed using k statistics. A total of 72/279 (25.8%) individuals were TST positive, while 107/279 (38.3%) were QFT-GIT positive. The overall agreement between QFT-GIT and TST was 70.9%, with k statistic of 0.35. Using different TST and QFT-GIT cut-offs, the best concordance value was obtained for QFT-GIT at > 2.64 IU/ml and TST at > 10mm (k = 0.409). Discordant results were found for 58 subjects (21%) with QFT-GIT positive/TST negative and 23 (8%) with QFT-GIT negative/TST positive. A high amount of discordance QFT-GIT+/TST- was described. QFT-GIT might increase the identification of LTBI cases among recent immigrants.
为评估管内结核菌素释放试验（QFT-GIT）与结核菌素皮肤试验（TST）在筛查近期移民到意大利人群中潜伏性结核感染（LTBI）时的一致性，对279名受试者同时进行了TST和QFT-GIT检测。采用k统计量分析一致性。共有72/279（25.8%）的个体TST呈阳性，而107/279（38.3%）的个体QFT-GIT呈阳性。QFT-GIT与TST之间的总体一致性为70.9%，k统计量为0.35。采用不同的TST和QFT-GIT临界值，当QFT-GIT>2.64 IU/ml且TST>10mm时获得了最佳一致性值（k = 0.409）。发现58名受试者（21%）出现结果不一致，即QFT-GIT阳性/TST阴性，23名受试者（8%）出现QFT-GIT阴性/TST阳性。描述了大量QFT-GIT阳性/TST阴性的不一致情况。QFT-GIT可能会增加近期移民中LTBI病例的识别率。
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