Yazdani N, Khorsandi-Ashtiani M, Rabbani-Anari M, Bassam A, Kouhi A
Otorhinolaryngology Research Centre, Department of Otolaryngology, Head and Neck Surgery, Tehran University of Medical Sciences, Amir-A'lam Hospital, Tehran, Iran.
Pak J Biol Sci. 2009 Oct 15;12(20):1385-7. doi: 10.3923/pjbs.2009.1385.1387.
Keratoacanthoma (KA) is a rapidly growing, low-grade neoplasm of pilo-sebaceous and hair follicle units which most often appears on the sun-exposed skin of the middle aged and older persons with multiple or localized occurrence. This tumor is dome-shaped nodule with a central keratinous plug. The etiology of this tumor is not obvious. Exposure to excessive sunlight is the most frequently noted responsible factor in the etiology of KA. About 80% of the tumors occur on the face. The histological features of the KA are often very similar to those of a cutaneous squamous cell carcinoma; however, the tumor structure usually provides a basis for their difference. There are many unusual cases of keratoacanthoma reported regarding site, size or other specifications. In this study, we excised a mass of nasal vestibule, a site far away sun-exposure. To our knowledge, this is the first case of nasal vestibular keratoacanthoma. For a clinician and a pathologist it is important to consider a benign lesion like Keratoacanthoma (KA) in the differential diagnosis of ulcerated nasal lesions and pay attention to differ it from Squamous Cell Carcinoma (SCC) which has a different and aggressive management.
角化棘皮瘤（KA）是一种生长迅速的低度肿瘤，起源于毛囊皮脂腺单位，多见于中老年人群暴露于阳光下的皮肤，可单发或多发。该肿瘤为圆顶状结节，中央有角质栓。其病因尚不明确。过度暴露于阳光下是KA病因中最常提及的相关因素。约80%的肿瘤发生在面部。KA的组织学特征通常与皮肤鳞状细胞癌非常相似；然而，肿瘤结构通常为两者的差异提供了依据。关于角化棘皮瘤的部位、大小或其他特征，有许多不寻常的病例报道。在本研究中，我们切除了一例位于鼻前庭的肿物，该部位远离阳光暴露区域。据我们所知，这是首例鼻前庭角化棘皮瘤。对于临床医生和病理学家而言，在鉴别诊断溃疡性鼻腔病变时考虑角化棘皮瘤（KA）这种良性病变非常重要，同时要注意将其与鳞状细胞癌（SCC）相鉴别，因为后者的治疗方式不同且具有侵袭性。
