抗炎治疗对选择性激光小梁成形术后眼压降低的影响。

The impact of anti-inflammatory therapy on intraocular pressure reduction following selective laser trabeculoplasty.

作者信息

Realini Tony, Charlton Judie, Hettlinger Marc

机构信息

West Virginia University Eye Institute, Morgantown, Huntington, West Virginia, USA.

出版信息

Ophthalmic Surg Lasers Imaging. 2010 Jan-Feb;41(1):100-3. doi: 10.3928/15428877-20091230-18.

DOI:10.3928/15428877-20091230-18

PMID:20128578

Abstract

BACKGROUND AND OBJECTIVE

To determine whether the use of postoperative topical anti-inflammatory therapy affects the intraocular pressure (IOP)-lowering efficacy of selective laser trabeculoplasty in eyes with primary open-angle glaucoma.

PATIENTS AND METHODS

In this prospective, randomized, observer-masked study, 25 participants with primary open-angle glaucoma following bilateral 360 degrees selective laser trabeculoplasty used prednisolone acetate 1% four times daily in one randomly selected eye for 1 week. IOP was assessed at baseline and 1 week, 1 month, and 3 months after selective laser trabeculoplasty.

RESULTS

Baseline IOP and selective laser trabeculoplasty treatment parameters were comparable in both groups. Mean IOP was similar in eyes that did and did not receive steroid therapy at 1 week (17.0 vs 16.3 mm Hg, respectively, P = .613), 1 month (16.8 vs 16.2 mm Hg, respectively; P = .571), and 3 months (16.0 vs 15.8 mm Hg, respectively; P = .819).

CONCLUSION

A 1-week course of topical prednisolone acetate 1% four times daily did not affect the IOP-lowering effect of selective laser trabeculoplasty in eyes with primary open-angle glaucoma.

摘要

背景与目的

确定术后局部抗炎治疗的使用是否会影响原发性开角型青光眼患者选择性激光小梁成形术的降眼压疗效。

患者与方法

在这项前瞻性、随机、观察者盲法研究中，25例双侧360度选择性激光小梁成形术后的原发性开角型青光眼患者，在一只随机选择的眼中每日4次使用1%醋酸泼尼松龙，持续1周。在选择性激光小梁成形术前基线以及术后1周、1个月和3个月评估眼压。

结果

两组的基线眼压和选择性激光小梁成形术治疗参数具有可比性。在1周时（分别为17.0和16.3 mmHg，P = 0.613）、1个月时（分别为16.8和16.2 mmHg；P = 0.571）以及3个月时（分别为16.0和15.8 mmHg；P = 0.819），接受和未接受类固醇治疗的眼睛平均眼压相似。