School of Medicine, University of Thessaly, Larissa, Greece.
Department of Ophthalmology, General Hospital of Trikala, Trikala, Greece.
Arq Bras Oftalmol. 2023 Oct 9;86(5):e20210353. doi: 10.5935/0004-2749.2021-0353. eCollection 2023.
We assessed the effects of anti-inflammatory treatment after selective laser trabeculoplasty through a systematic search of the MEDLINE, COCHRANE, and ClinicalTrials.gov. The outcome measures were intraocular pressure, anterior chamber inflammation, and discomfort. Evidence synthesis was performed using fixed effects or random-effects model according to the heterogeneity of the included studies. Heterogeneity was assessed using Q-statistic and I2. For an overall estimate of continuous outcomes, the mean differences and their 95% confidence intervals were applied, while odds ratios and their 95% confidence intervals were applied for dichotomous outcomes. Six studies were included in all. No significant difference was noted in the patients for intraocular pressure and discomfort when treated with anti-inflammatory drops. However, the patients showed benefit from reduced anterior chamber inflammation in the first postoperative week [FE OR=0.43, 95% CI=(0.19, 0.95), PQ=0.97, I2=0%], with no significant difference between the outcomes of non-steroidal anti-inflammatory drugs and steroids [FE OR=0.75, 95% CI=(0.20, 2.82), PQ=0.37, I2=0%]. Anti-inflammatory drops reduce anterior chamber inflammation after selective laser trabeculoplasty but showed no effect on the intraocular pressure.
我们通过系统检索 MEDLINE、COCHRANE 和 ClinicalTrials.gov，评估了抗炎治疗对选择性激光小梁成形术的影响。结局指标为眼压、前房炎症和不适。根据纳入研究的异质性，采用固定效应或随机效应模型进行证据综合。使用 Q 统计量和 I2 评估异质性。对于连续结局的总体估计，应用了均数差及其 95%置信区间，而对于二分类结局，则应用了比值比及其 95%置信区间。所有研究共纳入 6 项研究。应用抗炎滴眼剂治疗后，患者的眼压和不适无显著差异。然而，患者在前术后第 1 周表现出前房炎症减轻的益处[FE OR=0.43，95%CI=(0.19,0.95)，PQ=0.97，I2=0%]，非甾体抗炎药和类固醇的结局之间无显著差异[FE OR=0.75，95%CI=(0.20,2.82)，PQ=0.37，I2=0%]。抗炎滴眼剂可减轻选择性激光小梁成形术后的前房炎症，但对眼压无影响。
